Infiltrating lobular cancer is known for its diffuse growth pattern and difficult radiological visualization. Based on this review, infiltrating lobular cancer patients do not have a higher local recurrence risk after breast conserving therapy. Lobular histology should also be considered as a separate prognostic factor in favour of referral for radiotherapy after mastectomy.
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Clinical treatment score Post-5 Years (CTS5) predicts the benefit of postmastectomy radiotherapy in patients with T1-2N1 luminal breast cancer.
Breast
January 2025
Department of Radiation Oncology, Xiamen Cancer Quality Control Center, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. Electronic address:
Purpose: To investigate the clinical value of Clinical Treatment Score Post-5 Years (CTS5) to predict the survival benefits of postmastectomy radiotherapy (PMRT) of patients with T1-2N1 luminal breast cancer (BC).
Methods: Patients who were diagnosed with T1-2N1 luminal BC between 2010 and 2015 were included in the Surveillance, Epidemiology, and End Results database. The chi-square test, binomial logistic regression, Kaplan-Meier analysis, and multivariable Cox proportional hazard model were used for statistical analyses.
Prognostic value of tertiary lymphoid structures in triple-negative breast cancer: integrated analysis with the tumor microenvironment and clinicopathological features.
Front Immunol
December 2024
Translational Research Unit, Montpellier Cancer Institute Val d'Aurelle, Montpellier, France.
Background: In triple-negative breast cancer (TNBC), the most immunogenic breast cancer type, tumor-infiltrating lymphocytes (TILs) are an independent prognostic factor. Tertiary lymphoid structures (TLS) are an important TILs source, but they are not integrated in the current prognostic criteria.
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Invasive Lobular Carcinoma in the Screening Setting.
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Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
Invasive lobular carcinoma (ILC) is the second-most common histologic subtype of breast cancer, constituting 5% to 15% of all breast cancers. It is characterized by an infiltrating growth pattern that may decrease detectability on mammography and US. The use of digital breast tomosynthesis (DBT) improves conspicuity of ILC, and sensitivity is 80% to 88% for ILC.
View Article and Find Full Text PDFApo10 and TKTL1 in blood macrophages as potential biomarkers for early diagnosis of operable breast cancer.
Breast Cancer Res Treat
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Cancer Prevention Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfengdong Road, Yuexiu District, Guangzhou, 510060, Guangdong, China.
Objective: Blood macrophage Apo10 and TKTL1 detection is a novel, noninvasive cancer screening approach, but its relevance in breast cancer remains uncertain. We compared the potential diagnostic value of Apo10 and TKTL1 with commonly used tumor markers in differentiating breast cancer patients.
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Adipocyte heterogeneity and tumor infiltration of adipose tissue in patients with metastatic breast cancer.
Breast
November 2024
Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Belgium. Electronic address:
Background: The adipose tissue may serve as a source of energy supporting cancer growth and metastasis. Our understanding of the adipocytes which compose the adipose tissue in different anatomical locations of the body as well as potential microscopic tumor infiltration in patients with metastatic breast cancer remains limited. This study therefore investigates regional variations in adipocyte size and adipose tissue tumor infiltration in patients with metastatic breast cancer.
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