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| http://dx.doi.org/10.1016/S0140-6736(13)60125-7 | DOI Listing |
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Depression of cortical neuronal activity after a low-dose fentanyl in preterm infants.
Acta Paediatr
January 2025
Pediatrics, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.
Aim: Opioids might be harmful to the developing brain and dosing accuracy is important. We aimed at investigating fentanyl effects on cortical activity in infants using computational re-analysis of bedside recorded EEG signals.
Methods: Fifteen infants born at median 26.
From pre-test and post-test probabilities to medical decision making.
BMC Med Inform Decis Mak
July 2024
College of Information Science and Technology, Pennsylvania State University, University Park, PA, USA.
Background: A central goal of modern evidence-based medicine is the development of simple and easy to use tools that help clinicians integrate quantitative information into medical decision-making. The Bayesian Pre-test/Post-test Probability (BPP) framework is arguably the most well known of such tools and provides a formal approach to quantify diagnostic uncertainty given the result of a medical test or the presence of a clinical sign. Yet, clinical decision-making goes beyond quantifying diagnostic uncertainty and requires that that uncertainty be balanced against the various costs and benefits associated with each possible decision.
View Article and Find Full Text PDFFrom Pre-test and Post-test Probabilities to Medical Decision Making.
medRxiv
February 2024
College of Information Science and Technology, Pennsylvania State University, University Park, PA.
Background: A central goal of modern evidence-based medicine is the development of simple and easy to use tools that help clinicians integrate quantitative information into medical decision-making. The Bayesian Pre-test/Post-test Probability (BPP) framework is arguably the most well known of such tools and provides a formal approach to quantify diagnostic uncertainty given the result of a medical test or the presence of a clinical sign. Yet, clinical decision-making goes beyond quantifying diagnostic uncertainty and requires that that uncertainty be balanced against the various costs and benefits associated with each possible decision.
View Article and Find Full Text PDFSimple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension.
Drug Dev Ind Pharm
September 2022
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Objective: The study aimed to develop a rapid, simple and sensitive LC/ESI-MS/MS method to measure prazosin concentration in human plasma and apply bedside sampling in bioequivalence study of two prazosin tablets to resolve the adverse effect of orthostatic hypotension.
Significance: The LC/ESI-MS/MS prazosin method was highly sensitive and selective. Bedside sampling reduced the orthostatic hypotension incidence and subject dropout rate.
Personalized Positive End-Expiratory Pressure and Tidal Volume in Acute Respiratory Distress Syndrome: Bedside Physiology-Based Approach.
Crit Care Explor
July 2021
Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda, Maggiore Policlinico Hospital, Milan, Italy.
Unlabelled: Positive end-expiratory pressure and tidal volume may have a key role for the outcome of patients with acute respiratory distress syndrome. The variety of acute respiratory distress syndrome phenotypes implies personalization of those settings. To guide personalized positive end-expiratory pressure and tidal volume, physicians need to have an in-depth understanding of the physiologic effects and bedside methods to measure the extent of these effects.
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