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The Impact of Lebrikizumab on Vaccine-Induced Immune Responses: Results from a Phase 3 Study in Adult Patients with Moderate-to-Severe Atopic Dermatitis.
Dermatol Ther (Heidelb)
August 2024
allCUTIS Research, Portsmouth, NH, USA.
Article Synopsis
- Lebrikizumab, a monoclonal antibody targeting interleukin-13, was studied for its effects on immune responses to non-live vaccines in adults with moderate-to-severe atopic dermatitis (AD).
- The phase 3, double-blind study involved randomizing patients to receive either lebrikizumab or a placebo, with the main focus on responses to tetanus and meningococcal vaccines after 16 weeks.
- Results indicated similar Tdap booster responses between both groups, but lebrikizumab patients showed a significantly higher rate of positive response to the meningococcal vaccine and better improvement in AD symptoms compared to the placebo group.
Engineering of tetanus toxoid-loaded polymeric microneedle patches.
Drug Deliv Transl Res
March 2023
Leicester School of Pharmacy, De Montfort University, Leicester, UK.
This study is aimed to fabricate tetanus toxoid laden microneedle patches by using a polymeric blend comprising of polyvinyl pyrrolidone and sodium carboxymethyl cellulose as base materials and sorbitol as a plasticizer. The tetanus toxoid was mixed with polymeric blend and patches were prepared by using vacuum micromolding technique. Microneedle patches were evaluated for physical attributes such as uniformity of thickness, folding endurance, and swelling profile.
View Article and Find Full Text PDFA sewing needle in the liver in children: A case report and literature review.
Medicine (Baltimore)
July 2022
Department of Hepatobiliary Surgery, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China.
Rationale: In clinical practice, foreign bodies (FBs) in the digestive tract are more common in children, but intrahepatic FBs are rare, especially those that can cause infection, bleeding, bile leakage, and other complications. However, there is no consensus on its diagnosis and treatment due to the lack of large-scale cohort studies.
Patient Concerns: Case 1 is a 4-years 8-months-old girl, who at the age of 10 months, showed an X-ray finding of a striped FB in her liver, with no symptoms.
Health risks for body pierced community: a systematic review.
Public Health
April 2022
Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133, Naples, Italy. Electronic address:
Objective: Body piercing is defined as the penetration of jewellery into openings made in different body areas. In the last decades, it has become increasingly common in the general population. The aim is to analyse the available literature about complications from body piercing for contributing to raise the awareness towards this issue and to plan and perform appropriate prevention interventions.
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