Immediate and delayed photocontact dermatitis from the UVA absorber isopropyl dibenzoylmethane is described in 1 patient. In a dose response study in a 2nd patient with delayed photocontact dermatitis, the minimal dose of UVA needed to elicit a positive photopatch to isopropyl dibenzoylmethane 2% was determined to be 2 J/cm2.
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Contact allergy to oxidised geraniol may be over-represented in individuals with photocontact allergy to ketoprofen.
Contact Dermatitis
January 2024
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden.
Background: Simultaneous overrepresentations of contact allergies and photocontact allergies are common in individuals with photocontact allergy to ketoprofen.
Aims: To investigate whether contact allergy to oxidised (ox.) geraniol, geraniol, geranial, neral and citral is overrepresented in individuals with photocontact allergy to ketoprofen.
Contact allergy to fragrance mix I and its components in individuals with photocontact allergy to ketoprofen.
Contact Dermatitis
December 2021
Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Background: Contact allergy to fragrance mix I (FM I) is over-represented in patients photoallergic to ketoprofen. The prevalence of contact allergy to two components of FM I, cinnamal and cinnamyl alcohol, in ketoprofen-photoallergic patients is higher than in dermatitis patients.
Objective: To explore the prevalence of contact allergy to FM I and its individual components in patients with photocontact allergy to ketoprofen, and to compare with a dermatitis and the general population.
Abstract Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction mounting from skin exposure to generally harmless amounts of ultraviolet and/or visible light in the presence of a photoreactive allergen. These reactions are typically delayed type (Gell and Coombs type IV) reactions and require pre-sensitization to photoallergens. Phototoxic reactions are clinically similar and often difficult to differentiate from photoallergies, but they are caused by interaction of light with photoirritants and do not require sensitization.
View Article and Find Full Text PDFPhotoallergic contact dermatitis caused by ultraviolet filters in different sunscreens.
Int J Dermatol
November 2008
Department of Dermatology, University Medical Center Maastricht, The Netherlands.
Over the last decade, a change in the public awareness regarding the possible danger of excessive sunlight exposure has resulted in an increased consumption of sunscreens. These products contain a broad spectrum of putative sensitizers that can cause contact dermatitis and, upon exposure to ultraviolet (UV) irradiation, photocontact dermatitis. Among these sensitizing compounds, UV filters are the most frequent cause of photoallergic reactions.
View Article and Find Full Text PDFStimulation of Langerhans cells with ketoprofen plus UVA in murine photocontact dermatitis to ketoprofen.
J Dermatol Sci
August 2007
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Background: Ketoprofen (KP) clinically evokes the allergic type of photocontact dermatitis when applied to the skin and irradiated with ultraviolet A (UVA). We have established a murine model of photocontact dermatitis to KP, which is a T cell-mediated delayed type hypersensitivity.
Objective: To further explore the mechanism underlying this sensitivity, we investigated whether KP plus UVA activates the antigen-presenting ability of Langerhans cells (LCs).
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