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| http://dx.doi.org/10.3747/pdi.2012.00023 | DOI Listing |
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Sertraline exhibits in vivo antifungal activity against Candida auris and enhances the effect of voriconazole in combination.
Microb Pathog
December 2024
Universidad Autónoma de Nuevo León, Facultad de Medicina, Departamento de MicrobiologíaAve. Francisco I. Madero & Dr. Eduardo A. Pequeño, S/n. Colonia Mitras Centro, 64460, Monterrey, N.L, Mexico. Electronic address:
Article Synopsis
- * Researchers tested sertraline, a common antidepressant, for its antifungal properties and found it reduced fungal levels in mice infected with C. auris, particularly in the kidneys.
- * The combination of sertraline and voriconazole showed a stronger antifungal effect than either drug alone, suggesting a potential new treatment approach for C. auris infections.
A successful management of fungal peritonitis caused by Rhodotorula glutinis in CAPD patient, coincident with onychomycosis by Penicillium sp: Case report.
Medicine (Baltimore)
July 2023
Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Rationale: Rhodotorula glutinis is a rare cause of fungal peritonitis in peritoneal dialysis (PD) patients. The combination treatment between aggressive PD catheter replacement and adequate antifungal treatment is crucial in managing peritonitis due to fungal infection and onychomycosis.
Patient Concerns: A 37-year-old man PD patient presented with cloudy effluent, abdominal pain, and black debris in the lumen of his PD catheter.
, an emerging fungus causing peritonitis in a patient receiving peritoneal dialysis.
Med Mycol Case Rep
March 2023
Center of Excellence in Kidney Metabolic Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Fungal peritonitis (FP) is usually associated with poor patient outcomes and is mostly caused by non- species. We present a -associated peritonitis in a 68-year-old woman with end-stage kidney disease on peritoneal dialysis (PD). Biochemical profiling of the cultured yeast of the effluent sample did not adequately identify the yeast.
View Article and Find Full Text PDFEfficacy of amiodarone and voriconazole combination therapy in cutaneous leishmaniasis in the mice experimentally infected with Leishmania major.
J Infect Chemother
July 2021
Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Introduction: The aim of the present study was to evaluate in vitro and in vivo efficacy of combination therapy of amiodarone and voriconazole against Leishmania major and investigating immune and wound healing responses of cutaneous leishmaniasis to this combination therapy.
Methods: For in vitro study, replication of L. major promastigotes and intracellular amastigotes were investigated in the presence and absence of amiodarone and voriconazole.
Effects of Cinnamaldehyde on the Cell Wall of and Its Application in Treating Mice with Invasive Pulmonary Aspergillosis.
Evid Based Complement Alternat Med
October 2018
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
Background: The invasive pulmonary aspergillosis is a kind of high incidence of disease with difficulties in treatment, poor prognosis, and high mortality.
Objectives: The study aimed to reveal the effect of cinnamaldehyde on the fungal cell wall and verify its efficacy on invasive pulmonary aspergillosis on immunosuppressed Institute of Cancer Research mice (ICR mice).
Methods: ICR mice were given cyclophosphamide 200 mg.
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