AI Article Synopsis

  • * Researchers found that lower muscle attenuation (MA) was connected to issues like diabetes, high triglycerides, and hypertension in both men and women; however, these links often disappeared after considering body mass index (BMI) and visceral fat.
  • * Notably, while most associations faded with adjustments, women retained a significant link to metabolic syndrome, and men retained associations with lipid levels even after accounting for BMI and visceral fat.

Article Abstract

Objective: Intramuscular fat accumulates between muscle fibers or within muscle cells. We investigated the association of intramuscular fat with other ectopic fat deposits and metabolic risk factors.

Approach And Results: Participants (n=2945; 50.2% women; mean age 50.8 years) from the Framingham Heart Study underwent multidetector computed tomography scanning of the abdomen. Regions of interest were placed on the left and right paraspinous muscle, and the muscle attenuation (MA) in Hounsfield units was averaged. We examined the association between MA and metabolic risk factors in multivariable models, and additionally adjusted for body mass index (BMI) and visceral adipose tissue (VAT) in separate models. MA was associated with dysglycemia, dyslipidemia, and hypertension in both sexes. In women, per standard deviation decrease in MA, there was a 1.34 (95% confidence interval, 1.10-1.64) increase in the odds of diabetes mellitus, a 1.40 (95% confidence interval, 1.22-1.61) increase in the odds of high triglycerides, and a 1.29 (95% confidence interval, 1.12-1.48) increase in the odds of hypertension. However, none of these associations persisted after adjustment for BMI or VAT. In men, we observed similar patterns for most risk factors. The exception was metabolic syndrome, which retained association in women even after adjustment for BMI and VAT, and low high density lipoprotein and high triglycerides in men, whose associations also persisted after adjustment for BMI and VAT.

Conclusions: MA was associated with metabolic risk factors, but most of these associations were lost after adjustment for BMI or VAT. However, a unique association remained for metabolic syndrome in women and lipids in men.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696991PMC
http://dx.doi.org/10.1161/ATVBAHA.112.301009DOI Listing

Publication Analysis

Top Keywords

metabolic risk
16
risk factors
16
adjustment bmi
16
intramuscular fat
12
95% confidence
12
confidence interval
12
increase odds
12
bmi vat
12
framingham heart
8
heart study
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!