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| http://dx.doi.org/10.1093/carcin/bgt014 | DOI Listing |
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Modulation of Lymphotoxin β Surface Expression by Kaposi's Sarcoma-Associated Herpesvirus K3 Through Glycosylation Interference.
J Med Virol
January 2025
Department of Infection Biology, Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Kaposi's sarcoma-associated herpesvirus (KSHV) employs diverse mechanisms to subvert host immune responses, contributing to its infection and pathogenicity. As an immune evasion strategy, KSHV encodes the Membrane-Associated RING-CH (MARCH)-family E3 ligases, K3, and K5, which target and remove several immune regulators from the cell surface. In this study, we investigate the impact of K3 and K5 on lymphotoxin receptor (LTβR) ligands, LTβ and LIGHT, which are type II transmembrane proteins and function as pivotal immune mediators during virus infection.
View Article and Find Full Text PDFInterstitial lung disease (ILD) has shown limited treatment advancements, with minimal exploration of circulating protein biomarkers causally linked to ILD and its subtypes beyond idiopathic pulmonary fibrosis (IPF). In this study, we aimed to identify potential drug targets and circulating protein biomarkers for ILD and its subtypes. We utilized the most recent large-scale plasma protein quantitative trait loci (pQTL) data detected from the antibody-based method and ILD and its subtypes' GWAS data from the updated FinnGen database for Mendelian randomization analysis.
View Article and Find Full Text PDFIL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer.
Nature
January 2025
Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues, induces TLSs.
View Article and Find Full Text PDFDeletion of lymphotoxin-β receptor (LTβR) protects against acute kidney injury by PPARα pathway.
Mol Med
December 2024
Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan, 430030, China.
Article Synopsis
- Recent findings reveal that the lymphotoxin-β receptor (LTβR) plays a significant role in inflammation, but its exact functions in acute kidney injury (AKI) are still not well understood.
- In mouse models of AKI induced by renal ischemia-reperfusion, depletion of LTβR led to reduced kidney damage and inflammation, suggesting that LTβR primarily affects renal parenchymal cells during injury.
- RNA sequencing showed that the protective effects observed with LTβR depletion are linked to the activation of PPARα signaling, indicating that targeting the LTβR/PPARα pathway could offer new therapeutic strategies for managing AKI.
Low-grade systemic inflammation, but not neuroinflammation, is associated with 12-month postoperative outcome after total hip arthroplasty in patients with painful osteoarthritis.
Bone Joint Res
December 2024
Department of Neurology, Odense University Hospital, Odense, Denmark.
Article Synopsis
- The study aimed to improve the prediction of outcomes after total hip arthroplasty (THA) by examining the role of inflammatory biomarkers in blood and cerebrospinal fluid (CSF) related to osteoarthritis and pain.
- Researchers analyzed data from 50 patients, assessing changes in pain and disability 12 months post-surgery, while considering factors like age, sex, and BMI.
- Results showed that preoperative systemic inflammation in blood was linked to better postoperative outcomes, while neuroinflammation was tied to preexisting pain, suggesting that inflammatory biomarkers could help select patients for THA more effectively in the future.
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