Macrolide and rifampin resistance developed on a horse breeding farm after widespread use was instituted for treatment of subclinical pulmonary lesions in foals. Resistance occurred in 6 (24%) of 25 pretreatment and 8 (62%) of 13 (62%) posttreatment isolates from affected foals. Drug-resistant isolates formed 2 distinct genotypic clusters.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559061PMC
http://dx.doi.org/10.3201/eid1902.121210DOI Listing

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