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Synergistic design of CuO/CoFe₂O₄/MWCNTs ternary nanocomposite for enhanced photocatalytic degradation of tetracycline under visible light.
Sci Rep
January 2025
Department of Physics, Loyola College, Affiliated to the University of Madras, Chennai, 600034, India.
This study involves a novel CuO/CoFe₂O₄/MWCNTs (CCT) nanocomposite, developed by integrating cobalt ferrite (CoFe₂O₄) and copper oxide (CuO) nanoparticles onto multi-walled carbon nanotubes (MWCNTs), for the degradation of tetracycline (TC) under visible light. The photocatalyst was extensively characterized using XRD, HR-SEM, EDX, HR-TEM, UV-Vis, BET, and PL analysis. The synthesized CoFe₂O₄ and CuO nanoparticles exhibited crystallite sizes of 46.
View Article and Find Full Text PDFPhenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis.
Nat Rev Cardiol
January 2025
Department of Biomedical Sciences, and Department of Medicine, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, Los Angeles, CA, USA.
Computed tomography coronary angiography provides a non-invasive evaluation of coronary artery disease that includes phenotyping of atherosclerotic plaques and the surrounding perivascular adipose tissue (PVAT). Image analysis techniques have been developed to quantify atherosclerotic plaque burden and morphology as well as the associated PVAT attenuation, and emerging radiomic approaches can add further contextual information. PVAT attenuation might provide a novel measure of vascular health that could be indicative of the pathogenetic processes implicated in atherosclerosis such as inflammation, fibrosis or increased vascularity.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the challenges of diagnosing and managing cervical lesions in patients with Peutz-Jeghers syndrome (PJS) by analyzing MRI features in relation to pathological types.
- A total of 34 PJS patients were categorized into four groups based on their lesions, revealing significant differences in MRI characteristics, such as lesion extent and microcyst distribution.
- A new grading system was developed from these MRI findings to help assess the potential malignancy of cervical lesions, aiming to improve treatment recommendations and enhance collaboration between healthcare professionals.
Clinical and Molecular Analysis in Patients with Peutz-Jeghers Syndrome.
Turk J Gastroenterol
March 2024
Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylül University School of Medicine, İzmir, Turkey.
Article Synopsis
- Peutz-Jeghers syndrome (PJS) is a rare genetic disorder linked to heightened cancer risk, primarily due to mutations in the STK11 gene, with a study focusing on its manifestations and genetic profiles among 20 patients across 14 families.
- The research found that typical symptoms began around 18.9 years of age, with common issues including abdominal pain and specific polyps; 85% of patients had mucocutaneous lesions, and dysplastic polyps were present in some cases, leading to a few malignancies.
- The study successfully identified multiple pathogenic mutations, including 3 novel variants, and achieved high diagnostic rates with genetic testing; notable findings indicate that patients without mutations tend to show later symptom
Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response.
Br J Cancer
August 2024
Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.
Article Synopsis
- Researchers studied lung adenocarcinomas (LUAD) in non-tobacco users to find new genetic drivers of lung cancer, identifying 21 positively selected genes, including 12 that are novel in this context.* -
- One particularly important find was the SHPRH gene, which showed a link between low expression levels and poor survival outcomes in LUAD patients, indicating its potential role as a tumor suppressor.* -
- Reintroducing SHPRH in LUAD cell lines diminished tumor growth and the ability to form colonies, suggesting it’s critical for resistance against DNA damage, which could help predict patient responses to treatments.*
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