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Enzymatic Hydrolysis of Resorcylic Acid Lactones by an sp.
Toxins (Basel)
September 2024
London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
Zearalenone and radicicol are resorcylic acid lactones produced by numerous plant pathogenic fungi. Zearalenone is a non-steroidal estrogen mimic that can cause serious reproductive issues in livestock that consume contaminated feed. Radicicol is a potent inhibitor of the molecular chaperone Hsp90, which, in plants, has an important role in coordinating the host's immune response during infection.
View Article and Find Full Text PDFPerihematomal Neurovascular Protection: Blocking HSP90 Reduces Blood Infiltration Associated with Inflammatory Effects Following Intracerebral Hemorrhage in Rates.
Transl Stroke Res
September 2024
Department of Neurology and Stroke Center, Clinical Neuroscience Institute, The First Affiliated Hospital of Jinan University, 613 West Huangpu Ave, Guangzhou, 510632, China.
Article Synopsis
- Active hemorrhage in cerebral hematomas is linked to blood leaking into brain tissue due to ruptured vessels and inflammation, worsening neurological conditions in intracerebral hemorrhage (ICH) cases.
- High levels of heat shock protein 90 (HSP90) are found in ICH patients and are associated with increased inflammation, leading to deterioration of the blood-brain barrier (BBB).
- Blocking HSP90 with specific drugs (Geldanamycin and radicicol) has shown promise in reducing inflammation, improving neurological health, and preventing further bleeding by protecting the BBB in ICH models.
Taxonomy of Candida parapsilosis complex isolated from neonates and the role of Hsp90 inhibitors to enhanced the antifungal activity of micafungin.
Lett Appl Microbiol
May 2024
Federal University of Pernambuco, Mycology Department, Recife-PE, 50670-90, Brazil.
Species from Candida parapsilosis complex are frequently found in neonatal candidemia. The antifungal agents to treat this infection are limited and the occurrence of low in vitro susceptibility to echinocandins such as micafungin has been observed. In this context, the chaperone Hsp90 could be a target to reduce resistance.
View Article and Find Full Text PDFThe varicella-zoster virus ORF16 protein promotes both the nuclear transport and the protein abundance of the viral DNA polymerase subunit ORF28.
Virus Res
July 2024
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan. Electronic address:
Although all herpesviruses utilize a highly conserved replication machinery to amplify their viral genomes, different members may have unique strategies to modulate the assembly of their replication components. Herein, we characterize the subcellular localization of seven essential replication proteins of varicella-zoster virus (VZV) and show that several viral replication enzymes such as the DNA polymerase subunit ORF28, when expressed alone, are localized in the cytoplasm. The nuclear import of ORF28 can be mediated by the viral DNA polymerase processivity factor ORF16.
View Article and Find Full Text PDFA Chemical Chaperone Restores Connexin 26 Mutant Activity.
ACS Pharmacol Transl Sci
July 2023
Gottfried-Wilhelm-Leibniz University of Hannover, BMWZ (Zentrum für Biomolekulare Wirkstoffe), Schneiderberg 38, 30167 Hannover, Germany.
Mutations in connexin 26 (Cx26) cause hearing disorders of a varying degree. Herein, to identify compounds capable of restoring the function of mutated Cx26, a novel miniaturized microarray-based screening system was developed to perform an optical assay of Cx26 functionality. These molecules were identified through a viability assay using HeLa cells expressing wild-type (WT) Cx26, which exhibited sensitivity toward the HSP90 inhibitor radicicol in the submicromolar concentration range.
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