Objective: To evaluate the feasibility and accuracy of confocal laser endomicroscopy (CLE) for the in vivo diagnosis of colorectal cancer (CRC) compared with conventional histology.
Methods: Consecutive patients who had undergone CLE examination for screening or surveillance colonoscopy were recruited. Suspected malignant lesions and adjacent mucosal sites were first examined by confocal imaging and then biopsied specimens of these sites were obtained. The confocal images were independently interpreted by two endoscopists. The diagnosis made with CLE was compared with the conventional histological diagnosis in a prospective and blinded fashion.
Results: In total, 71 patients with suspected malignant lesions were included in the study. A total of 74 lesions and 92 adjacent mucosal sites were observed. The sensitivity, specificity and accuracy of CLE in diagnosing CRC were 97.1%, 99.0% and 98.2% for endoscopist A, and 98.6%, 96.9% and 97.6% for endoscopist B, respectively. The interobserver agreement between the two endoscopists was excellent (κ = 0.950). The accuracy of diagnosing poorly differentiated CRC using CLE was 97.0% for endoscopist A and 95.6% for endoscopist B.
Conclusion: CLE has the potential to enable an immediate diagnosis of CRC and the degree of differentiation of CRC during ongoing endoscopy in vivo.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1751-2980.12039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Na-K-ATPase/GLT-1 interaction participates in EGCG protection against cerebral ischemia-reperfusion injury in rats.
Phytomedicine
December 2024
Hebei Key Laboratory of Critical Disease Mechanism and Intervention, Department of Pathophysiology, Neuroscience Research Center, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, China. Electronic address:
Background: In China, stroke is the primary cause of adult death and disability. Because of the increased rate of blood vessel reperfusion, it is important to prevent cerebral ischemia-reperfusion injury, in which glutamate (Glu) excitotoxicity plays a critical role. The most important Glu transporter, GLT-1, is essential for the regulation of Glu, which is dependent on Na-K-ATPase (NKA)-induced ion concentration gradient differences.
View Article and Find Full Text PDFAnalysis of printing temperature effect on texture modification: Potential of soy protein isolate-based bigel for swallowing-friendly food.
Int J Biol Macromol
January 2025
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Institute of Western Agriculture, Chinese Academy of Agricultural Sciences, Changji 831100, China. Electronic address:
This work prepared the soy protein isolate (SPI)-beeswax-based bigel loaded with β-carotene, and the effect of printing temperature (PT) on texture regulation was investigated. During printing, increasing PT weakened the rheological properties and printability of ink. However, the mechanical strength and deformation resistance at non-linear regions of products were strengthened after printing.
View Article and Find Full Text PDFProtein aggregation behavior and structural characteristics in a lipoxygenase-linoleic acid-wheat gluten model system.
Int J Biol Macromol
January 2025
College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China. Electronic address:
This study explores the synergistic effects of linoleic acid (LA) oxidation on the aggregation behavior and structural properties of wheat gluten (WG). Using lipoxygenase to induce LA oxidation, it was observed that this process significantly influenced WG's viscoelasticity and structural characteristics. Specifically, LA oxidation enhanced WG's viscoelastic properties while reducing its instantaneous elastic and recovery deformations.
View Article and Find Full Text PDFPhysical and rheological properties of agglomerated milk protein isolate-guar gum mixtures: effect of binder type and concentration.
Food Sci Biotechnol
January 2025
Department of Food Science and Biotechnology, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang, 10326 Gyeonggi Korea.
Article Synopsis
- The study focused on how adding sugar and sugar alcohol binders in the fluidized-bed agglomeration process affects the physical properties of milk protein isolate (MPI) and guar gum (GG) mixtures.
- The agglomerated mixtures, known as AMGs, were found to have larger, more porous particles that improved solubility and flowability compared to non-agglomerated mixtures (NMG).
- However, AMGs had lower apparent viscosity and viscoelastic properties than NMG, which decreased further with more binder concentration, indicating a change in interaction between the protein and gum.
Effect of Cholic Acid Salt and Its Mixed Micelles on the Morphology of Giant Unilamellar Vesicles (GUV).
J Oleo Sci
January 2025
Faculty of Science and Technology, Tokyo University of Science.
Article Synopsis
- Bile salts act as biosurfactants in the gastrointestinal tract, helping to emulsify and absorb fat-soluble nutrients and drugs.
- The study utilized giant unilamellar vesicles (GUVs) to investigate the permeation behavior of bile salts and their mixed micelles, using sodium cholate (NaC) and various lipophilic substances.
- Findings showed that below the critical micelle concentration (CMC), NaC causes endocytic changes in GUVs, while above the CMC, mixed micelles interact with the membrane differently, forming aggregates that migrate into the GUV, with variations observed depending on the type of lipophilic component used.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!