AI Article Synopsis
- Ultramicroelectrode sensor arrays allow for the simultaneous detection of multiple chemical species by using specific chemistry for each analyte or for detailed mapping of a single analyte over time.
- Microfabrication techniques, particularly photolithography, are utilized to create these sensor arrays, commonly in thin-film microdisc configurations with various patterns like square or hexagonal shapes.
- The paper focuses on electrochemical sensor arrays designed for in vivo monitoring of nitric oxide (NO) levels in cultured cells and tissues, along with the simultaneous measurement of other related analytes.
Article Abstract
Ultramicroelectrode sensor arrays in which each electrode, or groups of electrodes, are individually addressable are of particular interest for detection of several species concomitantly, by using specific sensing chemistry for each analyte, or for mapping of one analyte to achieve spatio-temporal analysis. Microfabrication technology, for example photolitography, is usually used for fabrication of these arrays. The most widespread geometries produced by photolithography are thin-film microdisc electrode arrays with different electrode distributions (square, hexagonal, or random). In this paper we review different electrochemical sensor arrays developed to monitor, in vivo, NO levels produced by cultured cells or sliced tissues. Simultaneous detection of NO and analytes interacting with or released at the same time as NO is also discussed.
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| http://dx.doi.org/10.1007/s00216-012-6671-6 | DOI Listing |
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