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An Elderly Case of Minimal Change Nephrotic Syndrome: Correlation between Renal Tubular Dysfunction and the Onset of Oliguric Acute Kidney Injury Requiring Hemodialysis.
Case Rep Nephrol
April 2024
Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
Several theories have been proposed to explain the development of severe acute kidney injury (AKI) in patients with minimal change nephrotic syndrome (MCNS), but the exact mechanism remains unclear. We encountered an elderly patient with biopsy-proven MCNS who suffered from oliguric AKI, which required hemodialysis at the onset and during the first relapse of nephrotic syndrome. Throughout her relapse, we were able to monitor tubular injury markers, namely, urinary N-acetyl--D-glucosaminidase and urinary alpha-1-microglobulin levels.
View Article and Find Full Text PDFAlbuminuria, Forgotten No More: Underlining the Emerging Role in CardioRenal Crosstalk.
J Clin Med
January 2024
Nephrology Department, Germans Trias i Pujol University Hospital, 08916 Badalona, Spain.
Kidneys have an amazing ability to adapt to adverse situations, both acute and chronic. In the presence of injury, the kidney is able to activate mechanisms such as autoregulation or glomerular hyperfiltration to maintain the glomerular filtration rate (GFR). While these adaptive mechanisms can occur in physiological situations such as pregnancy or high protein intake, they can also occur as an early manifestation of diseases such as diabetes mellitus or as an adaptive response to nephron loss.
View Article and Find Full Text PDFSGLT2 Inhibitors and Diabetic Kidney Disease: Targeting Multiple and Interrelated Signaling Pathways for Renal Protection.
Curr Mol Pharmacol
October 2023
K.M.P THERAPIS Paphos Medical Center, Internal Medicine and Diabetes Clinic, 14 Vasileos Georgiou B Street, Office 201, 8010, Paphos, Cyprus.
Almost 20-40% of all patients suffering from diabetes mellitus experience chronic kidney disease, which is related to higher mortality (cardiovascular and all-cause). The implication of several pathophysiological mechanisms (hemodynamic, tubular, metabolic and inflammatory) in the pathogenesis of diabetic kidney disease generates an urgent need to develop multitarget therapeutic strategies to face its development and progression. SGLT2 inhibitors are undoubtedly a practice-changing drug class for individuals who experience type 2 diabetes and diabetic kidney disease.
View Article and Find Full Text PDFClinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease.
Ren Fail
September 2023
Department of Paediatrics, Jinling HospitalSchool of Medicine, Nanjing University, Nanjing, P.R. China.
Background: Acute interstitial nephritis (AIN) is a relatively rare cause of acute kidney injury (AKI) in children. Immune complex (IC) deposition was rare in renal pathology of AIN.
Methods: Based on the status and position of IC deposition, a total of 78 children with AIN were divided into two groups: the non-IC group and IC group.
Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption.
JCI Insight
October 2023
CHU Sainte-Justine Research Center, University of Montreal, Montreal, Québec, Canada.
Sialidosis is an ultra-rare multisystemic lysosomal disease caused by mutations in the neuraminidase 1 (NEU1) gene. The severe type II form of the disease manifests with a prenatal/infantile or juvenile onset, bone abnormalities, severe neuropathology, and visceromegaly. A subset of these patients present with nephrosialidosis, characterized by abrupt onset of fulminant glomerular nephropathy.
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