Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Net albumin leakage in patients in the ICU with suspected sepsis. A prospective analysis using mass balance calculations.
Crit Care
March 2025
Perioperative Medicine and Intensive Care, B31, Karolinska University Hospital, Huddinge, Sweden.
Introduction: Albumin kinetics in septic shock have been extensively studied, but clinical recommendations remain weak. An increased transcapillary escape rate (TER) of albumin has been demonstrated, though TER does not account for lymphatic return. Mass balance calculations, considering lymphatic return, have been used to assess net albumin leakage (NAL) in major surgery but not in sepsis.
View Article and Find Full Text PDFSeraph 100 Microbind Affinity Blood Filter for Persistent Pediatric BK Virus Nephropathy.
Pediatr Transplant
May 2025
Ann & Robert Lurie Childrens Hospital of Chicago, Chicago, Illinois, USA.
Background: Resolution of BK viremia is almost universally required before kidney transplant. Unfortunately, proven anti-BK viral therapies are limited. The Seraph 100 mimics the action of the natural glycocalyx, which binds pathogens via heparin sulfate proteoglycans.
View Article and Find Full Text PDFThe Mechanisms of Sepsis Induced Coagulation Dysfunction and Its Treatment.
J Inflamm Res
February 2025
Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
Sepsis is a critical condition characterized by organ dysfunction due to a dysregulated response to infection that poses significant global health challenges. Coagulation dysfunction is nearly ubiquitous among sepsis patients. Its mechanisms involve platelet activation, coagulation cascade activation, inflammatory reaction imbalances, immune dysregulation, mitochondrial damage, neuroendocrine network disruptions, and endoplasmic reticulum (ER) stress.
View Article and Find Full Text PDFSepsis-associated endothelial glycocalyx damage: a review of animal models, clinical evidence, and molecular mechanisms.
Int J Biol Macromol
March 2025
Department of Physiology, Naval Medical University, Shanghai 200433, China. Electronic address:
In the mammalian cardiovascular system, endothelial glycocalyx is a gel-like layer that covers the luminal surface of endothelial cells (ECs) and plays crucial roles in vascular homeostasis, permeability and leukocyte adhesion. Degradation of this structure occurs early in sepsis and becomes accordingly dysfunctional. In severe cases, it is not self-regulated by the organism.
View Article and Find Full Text PDFLactylation of Histone H3k18 and Egr1 Promotes Endothelial Glycocalyx Degradation in Sepsis-Induced Acute Lung Injury.
Adv Sci (Weinh)
February 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Circulating lactate is a critical biomarker for sepsis-induced acute lung injury (S-ALI) and is strongly associated with poor prognosis. However, whether elevated lactate directly promotes S-ALI and the specific mechanism involved remain unclear. Here, this work shows that lactate causes pulmonary endothelial glycocalyx degradation and worsens ALI during sepsis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!