Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC(50) value of 43.0 μM when evaluated using a zebrafish model.
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Jatropholane-type diterpenes from Euphorbia sikkimensis.
J Nat Prod
February 2013
Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Four new jatropholane-type diterpenes (1-4), named sikkimenoids A-D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1-4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC(50) value of 43.
View Article and Find Full Text PDFLagaspholones A and B: two new jatropholane-type diterpenes from Euphorbia lagascae.
Org Lett
February 2007
CECF, Faculty of Pharmacy, University of Lisbon, Avenida das Forças Armadas, 1600-083 Lisbon, Portugal.
[structure: see text] Two new diterpenes, lagaspholones A (1) and B (2), have been isolated from the methanolic extract of Euphorbia lagascae, along with the known compounds (+)-dehydrovomifoliol, scopoletin, dehydrodiconiferyl diacetate, 3-indolcarbaldehyde, and 4-hydroxy-3,5-dimethoxybenzaldehyde. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 contain the rare jatropholane-type skeleton, characterized by a 5:6:7:3 fused ring system.
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