AI Article Synopsis
- Sulfate-reducing bacteria and archaea play a crucial role in the sulfur cycle by converting sulfate (SO4(2-)) into hydrogen sulfide (H2S) through specific enzymatic processes.
- Recent studies focus on understanding how sulfate is activated to adenosine 5'-phosphosulfate (APS), then reduced to sulfite (SO3(2-)) and AMP, ultimately producing H2S.
- The review will also cover the structural mechanisms of three key enzymes involved in this process, highlighting their unique metal centers that facilitate the reactions.
Article Abstract
Sulfate-reducing bacteria and archaea are important players in the biogeochemical sulfur cycle. ATP sulfurylase, adenosine 5'-phosphosulfate reductase and dissimilatory sulfite reductase are the key enzymes in the energy conserving process of SO4(2-) → H2S reduction. This review summarizes recent advances in our understanding of the activation of sulfate to adenosine 5'-phosphosulfate, the following reductive cleavage to SO3(2-) and AMP, and the final six-electron reduction of SO3(2-) to H2S in the hyperthermophilic archaeon Archaeoglobus fulgidus. Structure based mechanisms will be discussed for these three enzymes which host unique metal centers at their catalytic sites.
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| http://dx.doi.org/10.1039/c2mt20225e | DOI Listing |
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