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| http://dx.doi.org/10.1073/pnas.1220841110 | DOI Listing |
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miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.
Nucleic Acids Res
June 2018
Department of Microbiology & Immunology, McGill University, Montréal, QC, Canada.
Hepatitis C virus (HCV) recruits two molecules of the liver-specific microRNA-122 (miR-122) to the 5' end of its genome. This interaction promotes viral RNA accumulation, but the precise mechanism(s) remain incompletely understood. Previous studies suggest that miR-122 is able to protect the HCV genome from 5' exonucleases (Xrn1/2), but this protection is not sufficient to account for the effect of miR-122 on HCV RNA accumulation.
View Article and Find Full Text PDFmiR-122 is more than a shield for the hepatitis C virus genome.
Proc Natl Acad Sci U S A
January 2013
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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