Bioactive carboxylic acids from Lysimachia clethroides.

J Asian Nat Prod Res

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Published: April 2013

Six new carboxylic acids (1-6), together with 11 known ones (7-17), were isolated from the aerial parts of Lysimachia clethroides. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. Five new carboxylic acids (1 and 3-6) were evaluated for their in vitro inhibitory activity against aldose reductase.

Download full-text PDF

Source
http://dx.doi.org/10.1080/10286020.2012.745855DOI Listing

Publication Analysis

Top Keywords

carboxylic acids
12
lysimachia clethroides
8
bioactive carboxylic
4
acids lysimachia
4
clethroides carboxylic
4
acids 1-6
4
1-6 7-17
4
7-17 isolated
4
isolated aerial
4
aerial parts
4

Similar Publications

Cinnamic acid lowers blood pressure and reverses vascular endothelial dysfunction in rats.

J Food Drug Anal

December 2024

Cardiovascular Research Group, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, University Road, Abbottabad-22060, KP, Pakistan.

Cinnamic acid (CA) possesses important cardiovascular effects such as cardioprotective, antiatherogenic, antihyperlipidemic and antioxidant, which predicts its potential role in the treatment of hypertension. The study was executed to investigate the antihypertensive potential of CA in Sprague Dawley (SD) rats followed by evaluation in diverse vascular preparations. Invasive blood pressure monitoring technique was used in normotensive and hypertensive rats, under anesthesia.

View Article and Find Full Text PDF

Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe and AA is generally recognized to be meaningful.

View Article and Find Full Text PDF

Nurse sharks (Ginglymostoma cirratum), especially juveniles, are often encountered by near-shore and shore-based recreational anglers and are suggested to exhibit minimal behavioral and physiological responses to capture, largely based on studies of adults using commercial or scientific fishing methods. To quantify the sub-lethal effects of recreational angling on juvenile nurse sharks, 27 individuals (across 31 angling events) were caught using hook-and-line fishing methods. Over a 30-min period, 4 blood samples were taken with variable time intervals between sampling (i.

View Article and Find Full Text PDF
Article Synopsis
  • The study explored the effects of a specific enzyme (FAEA) expressed in maize that targets the apoplast, focusing on its activity during the late stages of plant senescence and after storing the plant material.
  • FAEA levels increased until the reproductive (R) stage but dropped during full leaf senescence (R+), while the enzyme remained stable even after six months of cold storage.
  • The research found that FAEA expression led to decreased cell wall components like ferulates and improved the breakdown (saccharification) of plant material by enzymes, making it easier to extract sugars at later development stages.
View Article and Find Full Text PDF

Detrimental effects of terminal heat stress could be mitigated by exogenous application of synthetic compounds by preserving cell membrane integrity and protecting against oxidative damage. A field experiment was conducted to test the application of seven synthetic compounds on wheat growth traits: (1) thiourea (20 mM and 40mM); (2) potassium nitrate (1% and 2%); (3) sodium nitroprusside (400 μg mL-1 and 800μg mL-1 ); (4) dithiothreitol (25 ppm and 50ppm); (5) salicylic acid (100 ppm and 200ppm); (6) thioglycolic acid (200 ppm and 500ppm); and (7) putrescine (4 mM and 6mM). These compounds were applied at the anthesis and grain-filling stages to enhance physio-biochemical traits and yield attributes of wheat (Triticum aestivum ) cvs GW-11 and GW-496 under terminal heat stress.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!