AI Article Synopsis
Article Abstract
Background: Pleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.
Methods: We reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.
Results: The tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.
Conclusions: PC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540336 | PMC |
| http://dx.doi.org/10.4132/KoreanJPathol.2012.46.6.576 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cytological Features of Sialoblastoma: A Case Report With Summary of Prior Published Cases.
Cytopathology
December 2024
Department of Pathology, IPGME&R, Kolkata, India.
Background: Sialoblastoma is an uncommon salivary gland neoplasm seen predominantly in the paediatric age group. It poses diagnostic challenges to the pathologists because of its rarity.
Case Report: Here, we present the cytological features of a case of sialoblastoma in 5-month-old baby boy on imprint cytology.
Trends and impact of endoscopic ultrasound utilization for suspected intraductal papillary mucinous neoplasms.
Pancreatology
December 2024
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background: Multiple management guidelines for intraductal papillary mucinous neoplasms (IPMNs) have been published to improve risk stratification and resource utilization. This study aims to evaluate trends in endoscopic ultrasound (EUS) use and agreement between cross-sectional imaging and EUS for specific pancreas cystic lesion (PCL) features.
Methods: This retrospective cohort study included consecutive adults undergoing EUS for suspected IPMN detected with cross-sectional imaging (CT/MRCP) between 2013 and 2015 (Cohort 1) and 2018-2020 (Cohort 2).
Morphology of the head-associated exocrine glands in Cornitermes cumulans with the description of a novel gland for the worker caste.
Tissue Cell
December 2024
Laboratório de Comportamento e Ecologia de Insetos Sociais, Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Exocrine glands are important mediators of communication in eusocial insects and the description of novel glands reflects the complex context in which these animals live. Here we revisit the head-associated glands in workers of the Neotropical termite Cornitermes cumulans through histological analysis and describe a novel gland for this caste, the intramandibular glands. This structure is located underneath the cuticle of the dorsodistal part of each mandible.
View Article and Find Full Text PDFA rare perspective: fine-needle aspiration cytologic features of hyaline vascular type of Castleman disease: A case report.
Medicine (Baltimore)
December 2024
Departments of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei, China.
Rationale: Castleman disease, also known as Castleman syndrome, is a rare, nonmalignant lymphoproliferative disorder. The localized subtype of this disease is primarily the hyaline vascular type of Castleman disease (HVCD). Although this disease is a benign lesion, the histologic features are similar to those of some malignant lymphomas, so an accurate diagnosis of the disease is required.
View Article and Find Full Text PDFDiagnostic interobserver variability of atypia assessment in columnar cell lesions among a group of expert breast pathologists in the United Kingdom and the Republic of Ireland, on behalf of the UK national coordinating committee for breast pathology.
Histopathology
December 2024
School of Cancer and Pharmaceutical Sciences, Kings College London, London, UK.
Aims: Atypical ductal hyperplasia and flat epithelial atypia (FEA) have defined diagnostic criteria, yet there is variation in the interpretation of these criteria, particularly when the atypia is present in a background of columnar cell lesions (CCLs). This study focuses upon cases which are especially challenging or difficult to classify reproducibly according to existing criteria.
Methods And Results: Thirteen breast pathology experts were asked to classify 10 challenging cases with CLLs as atypical or non-atypical.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!