The Cavum Septi Pellucidi (CSP), Cavum Vergae (CV) and Cavum Veli Interpositi, are anatomical variants located in the midline of the brain. It is important to identify these conditions to distinguish them from other entities that may require treatment. In this paper, our purpose is to describe MR and CT findings of CSP, CV and Cavum Veli Interpositi, explaining the differential diagnosis.
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The Prevalence of Septo-Optic Dysplasia in Neonates with Absent Cavum Septi Pellucidi Identified During Routine Prenatal Imaging.
Am J Perinatol
January 2025
Department of Pediatrics, Division of Neonatology, Oregon Health & Science University, Portland, United States.
Objective: To determine the prevalence of septo-optic-dysplasia (SOD) in patients with prenatally identified absent cavum septi pellucidi (CSP), agenesis of the corpus callosum (ACC) or dysgenesis of the corpus callosum (DCC).
Study Design: This retrospective chart review investigated neonates prenatally diagnosed with an absent CSP, ACC, or DCC who were admitted to a single quaternary academic medical center in the Pacific Northwest between 2016-2023. This prenatal diagnosis prompted a routine and protocolized postnatal workup for SOD including laboratory evaluation, imaging, and specialty consultation.
Sonographic visualization and measurement of the fetal optic chiasm and optic tract and association with the cavum septum pellucidum.
J Perinat Med
December 2024
Department of Perinatology, City Hospital of Izmir, Izmir, Türkiye.
Article Synopsis
- The study aimed to evaluate the visibility of the fetal optic chiasm and optic tracts through ultrasound and establish reference values for mid-trimester fetuses.
- It included 154 normal fetuses at 19-23 weeks of gestation, measuring various dimensions using a specific ultrasound technique, successfully visualizing OC and OTs in 70.8% of cases.
- Results showed that the dimensions of OC and OTs were positively correlated with measurements of the cavum septum pellucidum, as well as other growth indicators like biparietal diameter and head circumference.
Can cavum septum pellucidum width and length measurements also be reliable indicators of corpus callosum measurements in normal fetuses?
J Clin Ultrasound
January 2025
Department of Perinatology, Izmir City Hospital, Izmir, Turkey.
Objective: To examine the association between cavum septum pellucidum (CSP) and corpus callosum (CC) length and width measurements in mid-trimester sonographic screening in normal fetuses.
Methods: This prospective cohort study examined 152 pregnant women who underwent mid-trimester sonographic fetal anomaly screening. CSP and CC lengths and their anterior, middle, and posterior width measurements were examined sonographically.
Detection of genomic variants by genome sequencing in foetuses with central nervous system abnormalities.
Ann Med
December 2024
Genetics and Prenatal Diagnosis Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Objective: Clinical validity of genome sequencing (GS) (>30×) has been preliminarily verified in the post-natal setting. This study is to investigate the potential utility of trio-GS as a prenatal test for diagnosis of central nervous system (CNS) anomalies.
Methods: We performed trio-based GS on a prospective cohort of 17 foetuses with CNS abnormalities.
Cavum Septum Pellucidum in Former American Football Players: Findings From the DIAGNOSE CTE Research Project.
Neurol Clin Pract
October 2024
Department of Rehabilitation Medicine (HA, OJ), New York University Grossman School of Medicine, New York, NY; NYU Concussion Center (HA), NYU Langone Health, New York, NY; Psychiatry Neuroimaging Laboratory (HA, LBJ, OJ, NK, HWC, EK, AC, TLTW, TB, OP, MJC, IKK, SB, MES), Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; cBRAIN (LBJ, TLTW, IKK), Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital, Ludwig-Maximilians-Universit¨at, Munich, Germany; Department of Biostatistics (FT-Z, YT), Boston University School of Public Health Boston, MA; Center for Clinical Spectroscopy (KB, APL), Department of Radiology, Brigham and Women's Hospital Boston, MA; Department of Physical Medicine and Rehabilitation (DD), Harvard Medical School Boston, MA; Department of Physical Medicine and Rehabilitation (DD), Massachusetts General Hospital Boston, MA; Department of Physical Medicine and Rehabilitation (DD), Spaulding Rehabilitation Hospital, Cambridge, MA; Department of Radiology (OP, APL, MES), Brigham and Women's Hospital, Harvard Medical School Boston, MA; Department of Psychiatry (OP, IKK, MES), Massachusetts General Hospital Boston, MA; Department of Neurology (CHA), Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV (CB); Department of Neurology (CB), University of Washington, Seattle, WA; Department of Neurology (LJB), New York University Grossman School of Medicine, New York, NY; Department of Population Health (LJB), New York University Grossman School of Medicine, New York, NY; Department of Ophthalmology (LJB), New York University Grossman School of Medicine, New York, NY; Department of Neurology (MLA, RAS), Boston University Alzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA; Graduate School of Systemic Neurosciences (IKK), Ludwig-Maximilians-Universität, Munich, Germany; Chambers-Grundy Center for Transformative Neuroscience (JLC), Pam Quirk Brain Health and Biomarker Laboratory, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium (EMR), Phoenix, AZ; Department of Psychiatry (EMR), University of Arizona, Tucson, AZ; Department of Psychiatry (EMR), Arizona State University, Phoenix, AZ; Neurogenomics Division (EMR), Translational Genomics Research Institute and Alzheimer's Consortium, Phoenix, AZ; Department of Anatomy and Neurobiology (RAS); Department of Neurosurgery (RAS), Boston University Chobanian & Avedisian School of Medicine, Boston, MA; and Department of Software Engineering and Information Technology (SB), École de technologie supérieure, Université du Québec, Montreal, Canada.
Article Synopsis
- Exposure to repetitive head impacts (RHI) correlates with chronic traumatic encephalopathy (CTE), which can only be diagnosed after death; the study explores the presence of a cavum septum pellucidum (CSP) in living former football players to understand its relation to RHI and potential CTE.
- The research involved 175 former players, both college and professional, and compared their CSP measurements to a control group without RHI exposure, assessing associations with cumulative head impact and traumatic encephalopathy syndrome (TES).
- Results indicated that former players had significantly higher CSP presence and ratio compared to controls, with professional players exhibiting an even greater ratio; however, there was no notable link between CSP and TES or provisional
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