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Advancements in electrochemical sensor technology for warfarin detection: a comprehensive review.
Anal Methods
December 2024
Biofuel and Renewable Energy Research Center, Department of Biotechnology, Faculty of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran.
Warfarin (WA), the most prescribed oral anticoagulant in patients with atrial fibrillation, is widely utilized for the treatment of various diseases, such as vascular disorders, venous thrombosis, and atrial fibrillation. However, its abnormal concentration is linked to a variety of disorders and diseases, namely bleeding while brushing teeth, skin tissue issues, hair loss, and chest pain. Therefore, WA monitoring in blood serum is vital due to its narrow therapeutic window.
View Article and Find Full Text PDFDeploying Validated Mass Spectrometry for Frontline Detection and Treatment of Human Poisoning by Long-Acting Anticoagulant Rodenticides.
Chem Res Toxicol
November 2024
Jesse Brown VA Medical Center and Department of Anesthesiology, University of Illinois College of Medicine in Chicago, Chicago, Illinois 60612, United States.
Article Synopsis
- * LAARs can cause severe bleeding (coagulopathy) in humans if blood levels exceed 10 ng/mL, leading to numerous poisonings each year.
- * Various analytical methods, mainly using liquid chromatography-mass spectrometry (LC-MS), have been developed to quickly identify and analyze LAARs in patients experiencing severe bleeding, and these methods are evaluated for their validation and clinical utility.
Determination of warfarin in volumetric absorptive microsampling by liquid chromatography-tandem mass spectrometry.
Heliyon
July 2024
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau, Pinang, 11800, Malaysia.
Objective: This study aims to develop and validate bioanalytical method for quantifying warfarin in VAMS samples using liquid chromatography tandem mass spectrometry (LC-MS/MS), directly implementing the method to patients receiving warfarin therapy.
Methods: The UPLC-MS/MS method was developed and optimized, with quercetin as the internal standard. Sample preparation was carried out using protein precipitation with methanol-acetonitrile (1:3 v/v).
Dual benefits of NBD-Cl fluorogenic action and sample pretreatment (SALLE) technology in the assessment of anticoagulant medication: Dabigatran in pharmaceutical capsules and plasma samples.
Luminescence
July 2024
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Dabigatran (DBG), marketed as Pradaxa, is an anticoagulant medication prescribed for the treatment and mitigation of blood clots and to lower the risk of stroke in individuals with the heart condition known as atrial fibrillation. This medication is specifically indicated for preventing blood clots post hip or knee replacement surgeries and in patients with a prior history of clots. Compared to warfarin, dabigatran serves as a viable alternative that does not necessitate routine blood monitoring tests.
View Article and Find Full Text PDFBinding studies of promethazine and its metabolites with human serum albumin by high-performance affinity chromatography and molecular docking in the presence of codeine.
Anal Bioanal Chem
August 2024
Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy of the University of Porto, 4050-313, Porto, Portugal.
Article Synopsis
- "Purple Drank" is a drink combining promethazine and codeine, known for its hallucinogenic effects but can be dangerous in high doses.
- The study investigated how these drugs bind to human serum albumin (HSA) using high-performance affinity chromatography, finding PMZ and its metabolites bind strongly to HSA while codeine has a lower binding affinity.
- Displacement experiments and molecular docking indicated that all three compounds bind to HSA at both sites, with competition mainly between PMZ and codeine occurring at site II, and the binding wasn't affected by the chirality (enantiomers).
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