AI Article Synopsis
- The isoflavonoid rotenone (1) was transformed through γ-irradiation, resulting in two new compounds named rotenoisins A (2) and (3).
- The structures of these new derivatives were identified using various spectroscopic techniques.
- Rotenoisins A (2) and (3) showed greater ability to inhibit pancreatic lipase and adipocyte differentiation in 3T3-L1 cells compared to the original rotenone.
Article Abstract
Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2012.12.003 | DOI Listing |
Publication Analysis
Top Keywords
radiolytic transformation
8
rotenone
4
transformation rotenone
4
rotenone potential
4
potential anti-adipogenic
4
anti-adipogenic activity
4
activity radiolytic
4
transformation isoflavonoid
4
isoflavonoid rotenone
4
rotenone γ-irradiation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!