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Successful venous thrombectomy for extensive cerebral venous and sinus thrombosis after failed diagnostic lumbar puncture.
Rofo
January 2025
Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.
With an incidence of 2-5 per million adults, cerebral venous and sinus thrombosis (CVST) is a rarity in the spectrum of cerebrovascular diseases. The etiology and symptomatic presentation are heterogeneous and diverse. CSVT is, therefore, often underdiagnosed.
View Article and Find Full Text PDFThe Improvement in Sleep Quality by Zizyphi Semen in Rodent Models Through GABAergic Transmission Regulation.
Nutrients
December 2024
Department of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
: Sleep, a process physiologically vital for mental health, faces disruptions in various sleep disorders linked to metabolic and neurodegenerative risks. seed (Zizy) has long been recognized for its diverse pharmacological attributes, including analgesic, sedative, insomnia, and anxiety alleviation. : In this study, the sleep-prolonging effects of Zizy extract (100, 200 mg/kg), along with their characterizing compounds jujuboside A (JuA) (5, 10 mg/kg), were evaluated in a mouse model under a pentobarbital-induced sleep.
View Article and Find Full Text PDFMulti-generational exposure of Daphnia magna to pharmaceuticals: Effects on colonization, reproduction, and habitat selection behavior.
Ecotoxicol Environ Saf
January 2025
Department of Ecology and Coastal Management, Institute of Marine Sciences of Andalusia (ICMAN - CSIC), Puerto Real 11519, Spain. Electronic address:
The presence of pharmaceuticals in the aquatic environment is increasing due to their growing use for human health. Although most studies are based on short exposures to these contaminants, the present study has emerged from the need to study pharmaceuticals in aquatic organisms over a long-term exposure to understand any multi-generational chronic effects and alterations regarding habitat selection. Therefore, this study shows: (1) the ability of Daphnia magna to colonize environments contaminated with caffeine, ibuprofen and fluoxetine, and (2) the effect of these pharmaceuticals on reproduction and habitat selection (under two scenarios: with and without food) after a long-term exposure period of three generations.
View Article and Find Full Text PDFMultiple hour antifibrotic drug release enabled by a thermosensitive quadpolymer.
Int J Pharm
January 2025
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710; Department of Chemistry and Biochemistry, North Carolina Central University, Durham, NC 27707. Electronic address:
Article Synopsis
- The study focuses on an innovative thermosensitive quadpolymer designed for injection to deliver anti-fibrotic drugs, specifically targeting uterine fibroids while potentially preserving fertility.
- The quadpolymer functions as an injectable solution at room temperature and transforms into a stable gel at body temperature, allowing for sustained release of the drug pirfenidone.
- Results showed that the pirfenidone-loaded quadpolymer effectively inhibited fibroid cell proliferation, indicating its potential as a localized treatment option for uterine fibroid therapy.
Characteristics of the drinking habits of people who overdose over-the-counter drugs: Insights from a nationwide Japanese survey.
PCN Rep
December 2024
Department of Drug Dependence Research, National Institute of Mental Health National Center of Neurology and Psychiatry Tokyo Japan.
Aim: To analyze the drinking habits of individuals who overdosed on over-the-counter (OTC) drugs, such as cough suppressants, antitussives, antipyretic analgesics, and combination cold medications, in Japan.
Methods: This cross-sectional study analyzed data collected from 2881 participants through a national survey conducted in Japan in 2023. Through a self-administered questionnaire, the participants were categorized into OTC (overdosed OTC drugs in the past year) and control (did not overdose OTC drugs) groups.
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