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Assembly of ceria-Nrf2 nanoparticles as macrophage-targeting ROS scavengers protects against myocardial infarction.
Front Pharmacol
January 2025
The Sixth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, The Fifth Affiliated Hospital, Guangzhou, China.
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide, and mitigating oxidative stress is crucial in managing MI. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a critical role in combating oxidative stress and facilitating cardiac remodeling post-MI. Here, we engineered Cerium oxide (CeO) nanoparticle-guided assemblies of ceria/Nrf2 nanocomposites to deliver Nrf2 plasmids.
View Article and Find Full Text PDFT14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown?
Pharmaceutics
December 2024
Department of Pharmaceutical Technology, Faculty of Natural Sciences I, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle/Saale, Germany.
Background/objectives: Bringing small interfering RNA (siRNA) into the cell cytosol to achieve specific gene silencing is an attractive but also very challenging option for improved therapies. The first step for successful siRNA delivery is the complexation with a permanent cationic or ionizable compound. This protects the negatively charged siRNA and enables transfection through the cell membrane.
View Article and Find Full Text PDFThe Evaluation, Diagnosis, and Management of Infantile Hemangiomas-A Comprehensive Review.
J Clin Med
January 2025
Department of Pediatric Surgery, Children's Hospital Zagreb, Ulica Vjekoslava Klaića 16, 10000 Zagreb, Croatia.
Infantile hemangioma (IH) is the most common pediatric benign vascular tumor. Its pathogenesis is still poorly understood, and it usually appears during the first few weeks of life and follows a characteristic natural course of proliferation and involution. Most IHs are small, benign, resolve spontaneously, and do not require active treatment but only active observation.
View Article and Find Full Text PDFExperimental Investigation on Macroscopic and Microscopic Mechanical Properties of Geopolymer-Stabilized Macadam.
Materials (Basel)
January 2025
School of Civil Engineering, Central South University, Changsha 410075, China.
Geopolymer, as a promising inorganic binding material, holds potential for use in constructing base layers for highway pavements. This study aims to evaluate the mechanical properties of geopolymer-stabilized macadam (GSM) at both the micro- and macro-scale by a series of tests, demonstrating that high-Ca GSM is a high-quality material for pavement base layers. The results demonstrated that GSM exhibits outstanding mechanical and fatigue properties, significantly surpassing those of cement-stabilized macadam (CSM).
View Article and Find Full Text PDFAdhesion Mechanism, Applications, and Challenges of Ocular Tissue Adhesives.
Int J Mol Sci
January 2025
Key Laboratory of Biology and Medical Engineering, School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550001, China.
Corneal injury is prevalent in ophthalmology, with mild cases impacting vision and severe cases potentially resulting in permanent blindness. In clinical practice, standard treatments for corneal injury involve transplantation surgery combined with pharmacological therapy. However, surgical sutures exhibit several limitations, which can be overcome using tissue adhesives.
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