Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with glucocorticoid-induced TNFR-related (GITR) regulate NK cell mediated antitumor responses and discuss its therapeutic implications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539674 | PMC |
| http://dx.doi.org/10.3389/fimmu.2012.00402 | DOI Listing |
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