AI Article Synopsis
- Sulfatases from enteric bacteria help break down heavily sulfated mucosal glycans.
- The study found that the aslA gene in Salmonella enterica requires a mildly acidic pH for its activity and expression.
- AslA's regulation is influenced by the EnvZ-OmpR and PhoPQ systems, which are important for the bacteria's ability to cause disease.
Article Abstract
Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592217 | PMC |
| http://dx.doi.org/10.1128/AEM.03707-12 | DOI Listing |
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