Standardized methodology for drug susceptibility testing of second line drugs is vital for treatment of multi/extensively drug resistant tuberculosis. Discrepancy between laboratory methods and clinical interpretation is well established for bacteriostatic drugs such as ethionamide. Optimization of the standard proportion sensitivity testing (PST) method for ethionamide was under taken in 235 Mycobacterium tuberculosis isolates from new and previously treated pulmonary tuberculosis patients. An additional higher concentration of 57 μg/ml was evaluated against at the standard 40 μg/ml concentration in PST method. Performance parameters and agreement between the two drug concentrations was higher indicating the efficiency of PST method at its present format at 40 μg/ml and additional higher concentration of 57 μg/ml as an alternative when required.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11274-013-1255-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification and expression analysis of P-type ATPase IIIA subfamily in Puccinia Striiformis f. sp. tritici.
BMC Genomics
January 2025
College of Plant Protection, Gansu Agricultural University, Lanzhou, 730070, China.
Background: Puccinia striiformis f. sp. tritici (Pst) causes wheat stripe (yellow) rust disease, which is one of the most destructive diseases affecting wheat worldwide.
View Article and Find Full Text PDFGlobal transcriptome changes during growth of a novel Penicillium coffeae isolate on the wheat stripe rust fungus, Puccinia striiformis f. sp. tritici.
Fungal Genet Biol
January 2025
Research School of Biology, The Australian National University, 134 Linnaeus Way, Canberra, ACT 2601, Australia. Electronic address:
Wheat stripe rust caused by the fungus Puccinia striiformis f. sp. tritici (Pst) is currently the most destructive disease of wheat.
View Article and Find Full Text PDFObstetric penicillin allergy evaluations.
J Allergy Clin Immunol Glob
February 2025
Division of Allergy, Immunology, Rheumatology, Rochester Regional Health.
Background: Penicillin allergy is reported in 5% to 15% of the world population, with 3% to 10% of pregnant women reporting the same. However, more than 90% of these patients can tolerate penicillin after appropriate evaluation. Penicillin is indicated for various issues that arise in pregnancy, and a history of allergy can have negative individual and public health consequences.
View Article and Find Full Text PDFLaboratory validation of patient-specific templating for total knee arthroplasty.
Sci Rep
January 2025
Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.
Patient-specific templating (PST), which is a sister procedure to patient-specific instrumentation (PSI) but hospital-based, is relatively less complex and less expensive than robotics and navigation. However, there are some concerns about the PST including the process of preoperative planning, 3D printing and material, positioning of PST intraoperatively, availability, and clinical value. The purpose of this study was to validate the technical accuracy and reliability of the PST technique in the lab and to report the outcomes of clinical application.
View Article and Find Full Text PDFEffect of Knee Joint Rotational Stability on Sport Performance After Anterior Cruciate Ligament Reconstruction.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2024
Department of Sport and Rehabilitation Medicine,Beijing Chao-Yang Hospital, Capital Medical University,Beijing 100020,China.
Objective To investigate the effects of rotation stability after anterior cruciate ligament reconstruction (ACLR) on subjective outcomes,sport performance,psychological readiness,and return to sport. Methods The patients who underwent ACLR in the Sports Hospital,National Institute of Sports Medicine,General Administration of Sport of China from January 2015 to January 2021 were followed up during the period from November 2022 to December 2023.The patients were grouped according to the results of the pivot shift test (PST) of the affected knee at the last follow-up visit.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!