A series of Melanin-concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments.
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Article Synopsis
- * Neurons in the lateral hypothalamus, specifically those producing orexin and melanin-concentrating hormone (MCH), play a crucial role in regulating the circadian period of the SCN.
- * Research shows that these peptides can shorten circadian rhythms in the SCN, and their absence leads to prolonged behavioral rhythms in constant darkness, highlighting their importance in circadian modulation.
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