Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clml.2012.12.008 | DOI Listing |
Publication Analysis
Top Keywords
cd30-positive cutaneous
4
cutaneous t-cell
4
t-cell lymphoma
4
lymphoma response
4
response brentuximab
4
brentuximab vedotin
4
vedotin illustrative
4
illustrative cases
4
cd30-positive
1
t-cell
1
Similar Publications
Anaplastic Large B-Cell Lymphoma: Cutaneous Presentations.
Cureus
October 2024
Department of Dermatology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Article Synopsis
- Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma marked by the presence of CD30 and can often be mistaken for other conditions due to its vague symptoms.
- A 10-year-old girl initially treated for a bacterial infection was later diagnosed with ALK-negative ALCL after a biopsy revealed the disease, with additional imaging showing lung involvement and a Murphy stage II classification.
- The case highlights the necessity of early biopsy and molecular testing when initial treatments don't work, emphasizing that prompt diagnosis and thorough examinations can significantly enhance treatment success and patient prognosis.
[Antibody-Drug Conjugate for Treating Leukemia and Lymphoma-The Present Status, Problems, and Future Development].
Gan To Kagaku Ryoho
July 2024
Dept. of Hematology and Oncology, University of Fukui.
Article Synopsis
- * In Japan, four ADCs are approved: gemtuzumab ozogamicin for acute myeloid leukemia, brentuximab vedotin for various types of Hodgkin's and T-cell lymphomas (showing improved progression-free survival), inotuzumab ozogamicin for B-cell acute lymphoblastic leukemia (with higher remission rates), and polatuzumab vedotin for diffuse large B-cell lymphoma (which also improves outcomes when used with standard chemotherapy).
- * Despite their
Cutaneous Lymphoma in a Tertiary Skin Hospital and Referral Centre in Nepal.
J Nepal Health Res Counc
June 2024
DI Skin Hospital and Referral Centre Private Ltd, Bansbari, Budanilkantha, Kathmandu, Nepal.
Article Synopsis
- Primary cutaneous lymphomas are rare skin cancers that do not have lymphomas outside the skin when they are diagnosed, and there is currently no data on this condition in Nepal.
- This study looked at 15 cases of cutaneous lymphomas diagnosed at a hospital in Kathmandu, with patients having a median age of 45 years and more males than females.
- The findings showed that 87% of the lymphomas were T-cell types, with mycosis fungoides being the most common subtype, while only 13% were B-cell lymphomas.
DUSP22-rearranged primary cutaneous CD30-positive T-cell lymphoproliferative disorders and adult T-cell leukemia/lymphoma frequently share the LEF1+/TIA1- immunophenotype.
Hum Pathol
August 2024
Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan; Department of Pathology, Taipei Medical University Hospital, Taipei, 110, Taiwan; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704, Taiwan. Electronic address:
Article Synopsis
- DUSP22 rearrangements are genetic changes found in certain types of lymphomas, particularly in systemic and primary cutaneous anaplastic large cell lymphoma, as well as lymphomatoid papulosis, with previous studies mainly highlighting S-ALCL.
- This study examined LEF1/TIA1 expression and MSC mutations in 23 cases of C-ALCL and LyP, finding DUSP22 rearrangements in eight cases and LEF1 expression present in 63% of those cases, while TIA1 was negative across the board.
- The research indicated that the rate of LEF1 expression in DUSP22-rearranged C-ALCL/LyP is lower than that in S-ALCL
[Clinicopathological features of primary mucosal CD30-positive T-cell lymphoproliferative disorders].
Zhonghua Bing Li Xue Za Zhi
July 2024
Department of Pathology, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China.
Article Synopsis
- The study focused on the clinicopathological features and differential diagnosis of primary mucosal CD30-positive T-cell lymphoproliferative disorders (pmCD30TLPD) by reviewing cases diagnosed between 2013 and 2023.
- Eight cases were analyzed, revealing that most patients were middle-aged, with lesions primarily in the oral and anal mucosa, showing various morphological characteristics and immunophenotypes.
- Despite the potential for misdiagnosis with other lymphoproliferative disorders, most patients had favorable outcomes, with only one succumbing to complications, emphasizing the importance of careful diagnosis and monitoring.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!