AI Article Synopsis
- A new group of compounds featuring a 4,5-dihydro-5-methylisoxazoline structure have been created to act as VLA-4 receptor antagonists.
- Compound (14p) demonstrated a strong binding affinity to the receptor at 4 nM.
- Additionally, this compound showed good metabolic stability in laboratory tests.
Article Abstract
A novel set of compounds containing a 4,5-dihydro-5-methylisoxazoline have been successfully designed as VLA-4 receptor antagonists. Compound (14p) had a high receptor binding affinity of 4 nM and also found to be metabolically stable in vitro.
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| http://dx.doi.org/10.1016/j.bmcl.2012.12.043 | DOI Listing |
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