Direct access to enantioenriched spiroacetals through asymmetric relay catalytic three-component reaction.

Org Lett

Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.

Published: February 2013

The gold(I)/chiral Brønsted acid relay catalysis enabled a highly stereoselective three-component reaction of salicylaldehydes, anilines, and alkynols to give aromatic spiroacetals in high yields and stereoselectivities.

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Source
http://dx.doi.org/10.1021/ol303188uDOI Listing

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