Non-umbilical cutaneous metastasis of a pancreatic adenocarcinoma.

BMJ Case Rep

Department of Surgery, Saint Joseph Mercy Health System, Ann Arbor, Michigan, USA.

Published: January 2013

Pancreatic adenocarcinoma is one of the deadliest human malignancies with the majority of cases diagnosed late in the course of the disease. Cutaneous metastases originating from pancreatic cancer are rare. The most common site reported is the umbilicus. Non-umbilical cutaneous metastases are far less common with only a few cases reported in the literature. Our case involved a 43-year-old man with pancreatic carcinoma who was offered resection and a Whipple procedure was planned. Intraoperatively, the patient was found to have a widely metastatic disease not seen on preoperative imaging. Postoperatively, cutaneous metastasis in the scalp was discovered. Although rare, the recognition of non-umbilical cutaneous metastases of pancreatic adenocarcinoma can be of value because they can not only detect an underlying tumour but also guide management.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604162PMC
http://dx.doi.org/10.1136/bcr-2012-007931DOI Listing

Publication Analysis

Top Keywords

non-umbilical cutaneous
12
pancreatic adenocarcinoma
12
cutaneous metastases
12
cutaneous metastasis
8
pancreatic
5
metastasis pancreatic
4
adenocarcinoma pancreatic
4
adenocarcinoma deadliest
4
deadliest human
4
human malignancies
4

Similar Publications

Umbilical therapy for promoting transdermal delivery of topical formulations: Enhanced effect and underlying mechanism.

Int J Pharm

March 2024

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Beijing Municipal Science & Technology Commission, Beijing 102488, China. Electronic address:

Umbilical paste therapy is a promising method to promote transdermal drug delivery of topical formulations. This work investigated the effect and mechanism of transdermal drug delivery through the umbilical skin. The transdermal permeation studies showed the phenomenon of higher cumulative penetration and faster penetration rates for drug through the umbilical skin compared with non-umbilical skin, namely umbilical pro-permeability.

View Article and Find Full Text PDF

The Importance of Reading the Skin: Cutaneous Metastases of Pancreatic Cancer, a Systematic Review.

J Clin Med

December 2023

Hepatopancreatobiliary and Liver Surgery, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, 35121 Padua, Italy.

Background: Pancreatic cancer is notorious for its aggressive nature and low survival rate, with less than 10% of patients surviving beyond five years. Early detection is difficult, but skin metastases can be a rare but significant indicator. This systematic review focuses on the epidemiology, clinical features, and histology of skin metastases from pancreatic cancer to determine their importance in early diagnosis and overall management of the disease.

View Article and Find Full Text PDF
Article Synopsis
  • Cutaneous metastases in pancreatic cancer (PC) are uncommon and primarily originate from tumors located in the tail of the pancreas.
  • A study of 40 patients revealed that the abdomen is the most common site for these metastases, with umbilical lesions being particularly prevalent.
  • The overall survival (OS) for patients with umbilical metastases was slightly better (13.7 months) compared to those with non-umbilical metastases (8.9 months), and genetic testing identified several pathogenic variants.
View Article and Find Full Text PDF

Background: Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common reported site of metastasis is the umbilicus, and this manifestation is known as the Sister Mary Joseph's nodule. Non-umbilical cutaneous metastases are far less common, with only a few cases reported in the literature.

View Article and Find Full Text PDF

Pancreatic ductal adenocarcinoma, an extremely aggressive cancer, has high metastatic potential. Cutaneous metastasis is very uncommon, representing only <10% of all cases, presenting mostly around the umbilical region. Non-umbilical metastasis is even rarer, and the significance remains unknown.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!