Bronchodilation test using metered aerosols is a simple but extraordinary reliable method of respiratory functional diagnostics. It is highly sensitive (92%) and absolutely specific (100%) for demonstration of a pathologic elevated tonus of the bronchial musculature. The importance for the choice of therapy is limited. The main advantage concerns the diagnostic classification of the obstructive bronchopulmonary diseases.
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[Pulmonary function tests in the family doctor's office].
MMW Fortschr Med
March 2006
Robert-Koch-Klinik, Klinikum St Georg, Leipzig.
The basic diagnostic work-up including history-taking, clinical findings, and simple functional tests alone, suffices to enable the family doctor to rapidly differentiate between an obstructive and a restrictive pulmonary disease. This in particular by determining the "Tiffenau index", the ratio of the forced expiratory volume FEV1 to the forced vital capacity FVC (FEV1/ FVC). The question as to whether an obstructive condition is due to COPD or bronchial asthma is decided on the basis of the bronchospasmolytic test to determine the reversibility of the airways obstruction.
View Article and Find Full Text PDF[Spirometry, pulse oximetry, brochospasmolytic test. The pillars of COPD diagnosis].
MMW Fortschr Med
April 2002
Robert-Koch-Klinik, Städtisches Klinikum St. Georg, Leipzig.
In addition to case history and clinical examination, the basic diagnostic work-up of chronic obstructive pulmonary disease comprises in particular lung function testing by means of spirometry. In the event of an uncertain diagnosis, or in a search for underlying causes, an additional EKG, chest X-ray and bronchospasmolytic testing to determine the reversibility of the airways obstruction are employed. In COPD patients younger than 50, as well as in those with pulmonary edema largely confined to the basal fields, determination of the alpha-1-antitrypsin should be carried out.
View Article and Find Full Text PDFAim: To compare respiratory function in adults and children whose heart chordae were in anomalous position (AC) with reference to severity of heart connective tissue dysplasia syndrome.
Materials And Methods: The study included ninety one 6-14-year-olds and 125 adults with AC. The patients were divided into groups by the degree of atrioventricular valvular prolapse (AVVP).
In vitro and in vivo effects of SCA40 on guinea pig airways.
Naunyn Schmiedebergs Arch Pharmacol
February 1997
Sandoz Pharma Ltd., Basel, Switzerland.
SCA40 (6-bromo-8-methylaminoimidazo [1,2-a]-pyrazine-2-carbonitrile), a compound which had been described as an opener of Ca(2+)-dependent large conductance potassium channels (BKCa channels), was investigated in comparison with salbutamol for in vitro and in vivo bronchospasmolytic effects and for the ability to reverse airways hyperreactivity in guinea pigs. SCA40 reduced the spontaneous tone of isolated guinea pig tracheal rings with a biphasic concentration-response curve (first phase: pD2 = 8.0, EMax = 29.
View Article and Find Full Text PDFBronchospasmolytic activity and toxicity modelling of theophylline derivatives by a microcomputer based method.
Arzneimittelforschung
December 1993
Burgas University of Technology, Bulgaria.
The OASIS (Optimized Approach based on Structural Index Sets) microcomputer system was applied to model the bronchospasmolytic activity and toxicity of theophylline derivatives. The geometric and electronic factors responsible for biological activity of these compounds were determined. The molecular topology rather than compound metrics is the factor conditioning the theophylline activity.
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