Due to the emergence of drug-resistant strains and the cumulative toxicities associated with current therapies, demand remains for new inhibitors of HIV-1 replication. The HIV-1 matrix (MA) protein is an essential viral component with established roles in the assembly of the virus. Using virtual and surface plasmon resonance (SPR)-based screening, we describe the identification of the first small molecule to bind to the HIV-1 MA protein and to possess broad range anti-HIV properties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557583 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2012.11.041 | DOI Listing |
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