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Factors affecting behaviors during complementary feeding in infants and children aged 6-24 months.
PLoS One
January 2025
Vitamince Nutrition Counseling, Maltepe/Istanbul, Turkey.
The process that begins around the 6th month of life and continues until the 24th month is called the complementary feeding period. During this period, infants and children start receiving foods that complement breast milk or formula for the first time. The psychosocial factors the infants and children encounter during this period may affect their growth and health in later life.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Background: Classical genome-wide association studies (GWAS) of Alzheimer's disease (AD), which successfully identified over 75 risk loci to date, are limited to the content of the imputation panels that typically do not cover all types of genetic variation, e.g., tandem repeats encompassing >55% of human genome.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Background: It remains unclear to what extent global cognition translates to everyday functioning, although this is essential to interpreting the clinical meaningfulness of cognitive deficits. Here, we investigate potential linking between the Mini-Mental State Examination (MMSE) and the proxy-based Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q).
Methods: Cross-sectional data from 1228 amyloid-positive participants (age = 64±7yrs; 51.
Clinical Manifestations.
Alzheimers Dement
December 2024
Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
Background: Intrinsic capacity (IC) and frailty are inter-related yet distinct constructs which encapsulate functional capacities of older adults. There is uncertainty how IC is related to and interacts with the social (SF) and physical (PF) dimensions of frailty to influence cognition. We aim to examine IC, PF and SF profiles and compare the association between identified subtypes with change in cognition at 2 years METHODS: We studied 230 healthy community-dwelling older adults (age:67.
View Article and Find Full Text PDFBayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.
Genet Epidemiol
January 2025
JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an outcome of interest, for example, disease risk in a GWAS, at high levels of statistical significance, but with very small effects.
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