AI Article Synopsis
- Five new dibenzocyclooctadiene lignans named schisphenlignans A-E were discovered from the stems of Schisandra sphenanthera, alongside eight previously known lignans.
- The structural details of these new compounds were determined using NMR, MS, and circular dichroism spectroscopy techniques.
- Lab tests on the isolates indicated that they did not significantly improve insulin sensitivity in adipocyte cells when administered at a concentration of 10 µM.
Article Abstract
Five new dibenzocyclooctadiene lignans, schisphenlignans A-E (1-5), together with eight known ones, were isolated from the stems of Schisandra sphenanthera. The structures of 1-5 were elucidated based on the analysis of their NMR, MS and circular dichroism (CD) spectra. Some isolates were tested for their acute activities on insulin sensitivity in 3T3-L1 differentiated adipocytes, but none of them showed significant bioactivity with 10 µM administration of the tested compounds.
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| http://dx.doi.org/10.1248/cpb.c12-00700 | DOI Listing |
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