AI Article Synopsis
- Ectopic ACTH-secreting tumors are a rare cause of Cushing's syndrome, making up about 10% of cases.
- A unique case involved an ACTH-secreting pituitary adenoma found in the ethmoid sinus, discovered using Ga-68-DOTANOC PET/CT imaging.
- After the tumor was surgically removed through a transnasal endoscopic procedure, the patient experienced significant health improvement and normalization of hormone levels.
Article Abstract
Ectopic adrenocorticotropic hormone (ACTH)-secreting tumors account for approximately 10% of Cushing's syndrome (CS). We present an extremely rare case of a patient with CS caused by an ectopic ACTH-secreting pituitary adenoma (EAPA) of the ethmoid sinus. The tumor was identified by positron-emission tomography-computed tomography (PET/CT) using the somatostatin receptor analogue Ga-68-DOTANOC. Transnasal endoscopic resection was performed and the patient showed significant clinical improvement with normalization of the endocrine pituitary axis. Immunostaining showed a somatostatin receptor 2 and 5-positive ACTH-producing adenoma. In patients with ectopic ACTH secretion, Ga-68-DOTANOC-PET/CT may play an important role in the localization of EAPA. Transnasal endoscopic resection is the therapy of choice.
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| http://dx.doi.org/10.1002/lary.23867 | DOI Listing |
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