AI Article Synopsis
- - The study aimed to evaluate how long fetal exposure to inflammation affects the neurological development of newborn rats after being exposed to lipopolysaccharides (LPS).
- - Researchers injected pregnant rats with LPS at various times before delivery and found that longer exposure led to increased mortality and lower motor activity in the pups, particularly in those exposed for 12 hours.
- - The findings suggest that there is a critical time limit for preventing brain damage due to inflammation during pregnancy, indicating the need for timely deliveries in such cases.
Article Abstract
Objective: To determine the impact of the duration of fetal exposure to inflammation on the neurological outcome of pups.
Method: Time-pregnant Sprague-Dawley rats (n = 32) received intraperitoneal injection of lipopolysaccharides (LPS; 500 µg/kg), or an equivalent volume of vehicle 3, 6, 12 and 24 h before C-section. Maternal serum and amniotic fluid were tested for cytokines. Motor activity of resuscitated pups (n = 58) was analyzed using the open-field test (20 d). Brains were collected for histopathological examination.
Results: Perinatal mortality increased with the duration of fetal exposure to LPS. All parameters tested with the open-field test were lower in the LPS 12 h exposure group compared to the control group (p < 0.05). Tissue inhibitor of metalloproteinase 1 (TIMP-1) was statistically increased in maternal blood after 3, 6 and 12 h of LPS injection (p < 0.05 versus control).
Conclusion: A threshold of duration of exposure to inflammation is demonstrated, before which delivery should be performed in order to prevent brain damage.
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| http://dx.doi.org/10.3109/14767058.2012.755164 | DOI Listing |
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