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Cholelithiasis is frequently associated with carcinoma of gallbladder, and the presence of Salmonella Typhi in gallbladder of patients suffering from cholelithiasis is implicated as a predisposing factor for carcinogenesis. This study was conducted on patients suffering from chronic cholelithiasis from a region in North India-endemic area for enteric fever with high incidence of gallstones and gallbladder cancer. Since culture studies rarely reveal the chronic Salmonella Typhi persistence, we use PCR assay to specifically amplify the H1-d flagellin gene sequence homologous with Salmonella Typhi.

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Introduction: Laparoscopic cholecystectomy is a method of choice in the treatment of symptomatic cholecystolithiasis because of less postoperative pain, shorter hospitalization and lower cost of treatment. The study was aimed at analysing the outcome of laparoscopic cholecystectomy in patients surgically treated for chronic calculous cholecystitis (symptomatic cholelithiasis).

Material And Methods: The research was done in the period from December 2003 to December 2008.

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An analysis of 19,167 autopsies revealed, as a conformity of gallbladder carcinomas with and without cholelithiasis a statistical proved preference of women in gallbladder carcinomas. The difference in the age and relative sex distribution of gallbladder carcinomas with and without concrements demonstrates the influence of cholelithiasis in gallbladder carcinomas.

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