AI Article Synopsis
- Proteoglycans (PGs) are special proteins that help make up the surface of cells and the area around them in the brain.
- They are really important for the growth and health of the brain and help in forming the central nervous system (CNS).
- PGs also play a part in brain injuries and are connected to diseases like Alzheimer's, which affects memory and thinking.
Article Abstract
Proteoglycans (PGs) are major components of the cell surface and extracellular matrix and play critical roles in development and maintenance of the central nervous system (CNS). PGs are a family of proteins, all of which contain a core protein to which glycosaminoglycan side chains are covalently attached. PGs possess diverse physiological roles, particularly in neural development, and are also implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). The main functions of PGs in the CNS are reviewed as are the roles of PGs in brain injury and in the development or treatment of AD.
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| http://dx.doi.org/10.1002/iub.1118 | DOI Listing |
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