AI Article Synopsis
- Porphyria cutanea tarda (PCT) is a condition caused by a partial deficiency of the uroporphyrinogen-decarboxylase enzyme and is the most common type of porphyria.
- It can be triggered by factors such as alcohol, hepatitis C, HIV, and certain medications, including antiretroviral therapy.
- The text focuses on three HIV-positive patients who developed symptoms like photosensitivity and blisters on sun-exposed skin while undergoing highly active antiretroviral therapy (HAART), suggesting a link between the treatment and the onset of PCT.
Article Abstract
Porphyria cutanea tarda (PCT) is caused by inherited or acquired partial deficiency of the uroporphyrinogen-decarboxylase (Uro-D) enzyme activity. It is the most common form of porphyria. The main triggering factors to the development of porphyria cutanea tarda are alcohol, hepatitis C virus and human immunodeficiency virus. There are several reports of PCT associated with drugs, among them, antiretroviral therapy. We describe three HIV-positive patients, which showed photosensitivity as well as the emergence of tense blisters on sun-exposed areas during the use of highly active antiretroviral therapy (HAART) and discuss the possibility of PCT after the use of these drugs by those patients.
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| http://dx.doi.org/10.1590/s0037-86822012000600022 | DOI Listing |
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