AI Article Synopsis
- Rotavirus is a leading cause of severe diarrhea in young children, particularly in developing countries, impacting over 125 million annually.
- This study, conducted from October 2010 to February 2012 in Andaman and Nicobar Islands, analyzed 296 stool samples from children with gastroenteritis, finding 47 positive for GARV.
- The G2P[4] genotype was the most prevalent, but the increased presence of G9 rotavirus highlights the importance of including G9 in future vaccine development.
Article Abstract
Rotavirus is the most common cause of severe diarrhoea worldwide, affecting over 125 million young children every year in developing countries. The present study is a part of ongoing childhood diarrhoeal surveillance to determine the strain diversity of rotaviruses prevalent in Andaman and Nicobar Islands. From October 2010 to February 2012, 296 stool samples from children (age group 6-60 months) with gastroenteritis were obtained from different referral hospitals/primary health centres and community health centres in Andaman and Nicobar Islands. A total of 47 samples were found positive for GARV. Among these, 21 (44.7%) samples belong to G2P[4], 12 (25.5%) samples were G1P[8], 10 (21.2%) samples belong to G9P[4], 2 (4.3%) samples belong to G1P[4] and 2 (4.3%) samples had a mixed genotype. Rotavirus G2 genotype remains the most common genotype in these islands. The prevalence of G9 rotavirus reported in the present study is higher than that reported from mainland India. The results emphasize the role of the unusual serotype G9 as an epidemiologically important genotype and the need to include G9 specificity in a rotavirus vaccine.
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| http://dx.doi.org/10.1159/000342219 | DOI Listing |
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