In PET/MR systems having the PET component within the uniform magnetic field interior to the MR, positron beams can be injected into the PET field of view (FOV) from unshielded emission sources external to it, as a consequence of the action of the Lorentz force on the transverse components of the positron's velocity. Such beams may be as small as a few millimeters in diameter, but extend 50 cm or more axially without appreciable divergence. Larger beams form 'phantoms' of annihilations in air that can be easily imaged, and that are essentially free of γ-ray attenuation and scatter effects, providing a unique tool for characterizing PET systems and reconstruction algorithms. Thin targets intersecting these beams can produce intense annihilation sources having the thickness of a sheet of paper, which are very useful for high resolution measurements, and difficult to achieve with conventional sources. Targeted beams can provide other point, line and surface sources for various applications, all without the need to have radioactivity within the FOV. In this paper we discuss the physical characteristics of positron beams in air and present examples of their applications.
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http://dx.doi.org/10.1088/0031-9155/58/3/L1 | DOI Listing |
Mol Cancer Ther
December 2024
National Center for Tumor Diseases, Heidelberg, Germany.
Ultra-high dose rate radiotherapy with electrons and protons has shown potential for cancer treatment by effectively targeting tumors while sparing healthy tissues (FLASH effect). This study aimed to investigate the potential FLASH sparing effect of ultra-high-dose rate helium ion irradiation, focusing on acute brain injury and subcutaneous tumor response in a preclinical in vivo setting. Raster-scanned helium ion beams were used to compare the effects of standard dose rate (SDR at 0.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Key Laboratory of Materials Modification by Laser, Ion, and Electron Beams (Ministry of Education), School of Physics, Dalian University of Technology, Dalian 116024, People's Republic of China.
We present a novel resonance mode in capacitive radio frequency (rf) discharges in the presence of an oblique magnetic field at low pressures. We observe the self-excitation of high-frequency harmonics of the current in magnetized capacitive rf discharges through the magnetized plasma series resonance (MPSR) induced by applying a low-frequency power. Utilizing an equivalent circuit model, we reveal that these harmonics arise from the hybrid combination of the magnetic gyration of electrons and the PSR.
View Article and Find Full Text PDFPhys Rev E
November 2024
Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles, California 90095, USA.
We demonstrate that in situ coherent diffractive imaging (CDI), which leverages the coherent interference between strong and weak beams to illuminate static and dynamic structures, can serve as a highly dose-efficient imaging method. At low doses, in situ CDI can achieve higher resolution than perfect lenses with the point spread function as a delta function. Both our numerical simulations and experimental results demonstrate that combining in situ CDI with ptychography can reduce the required dose by up to two orders of magnitude compared with ptychography alone.
View Article and Find Full Text PDFMed Phys
December 2024
Dosimetry for Radiotherapy, Physikalisch-Technische Bundesanstalt, Braunschweig, 38116, Germany.
Background: FLASH radiotherapy is an emerging treatment modality using ultra-high dose rate beams. Much effort has been made to develop suitable dosimeters for reference dosimetry, yet the spatial beam characteristics must also be characterized to enable computerized treatment planning, as well as quality control and service of a treatment delivery device. In conventional radiation therapy, this is commonly achieved by beam profile scans in a water phantom using a point detector.
View Article and Find Full Text PDFSensors (Basel)
November 2024
Laboratori Nazionali di Frascati, INFN, Via E. Fermi 54, 00044 Frascati, Italy.
The SIDDHARTA-2 collaboration has developed a novel X-ray detection system based on cadmium-zinc-telluride (CZT, CdZnTe), marking the first application of this technology at the DAΦNE electron-positron collider at INFN-LNF. This work aims to demonstrate the stability of the detectors' performance in terms of linearity and resolution over short and long periods, thereby establishing their suitability for precise spectroscopic measurements within a collider environment. A reference calibration spectrum is presented in association with findings from assessments of linearity and resolution stability.
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