Objective: The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia.
Material And Methods: This research took the form of a double-blind, randomized clinical trial. Forty-one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first 'intervention group' (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second 'control group' (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.
Results: XI scores decreased significantly (clinically meaningful) from 36.4 ± 7.3 points to 29.1 ± 7.1 (p < 0.05) with an XI difference of 7.2 ± 6.1, after the combination among 1% malic acid with xylitol and fluoride application. After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < 0.05).
Conclusion: A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ger.12034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Integration of transcriptomics and metabolomics reveals the mechanism of Glycyrrhizae Radix Et Rhizoma extract inhibiting CCL5 in the treatment of acute pharyngitis.
Phytomedicine
January 2025
Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health, Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and Transformation, School of Pharmaceutical Sciences, Jinhua Academy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China. Electronic address:
Background: Acute pharyngitis (AP) is a common condition marked by inflammation of the oropharynx, which can lead to severe throat swelling, breathing difficulties, and even suffocation, significantly impacting quality of life. Despite the beneficial anti-inflammatory activity of Glycyrrhizae Radix Et Rhizoma (GRER) and Isoliquiritigenin (ISL), their pharmacological mechanisms against AP remain unclear.
Purpose: This study explores the mechanisms by which GRER treats AP, utilizing both transcriptomics and metabolomics approaches.
The combination of metagenomics and metabolomics reveals the effect of nitrogen fertilizer application driving the remobilization of immobilization remediation cadmium and rhizosphere microbial succession in rice.
J Hazard Mater
January 2025
College of Chemical and Environmental Engineering, Hanjiang Normal University, Shiyan 442000, China. Electronic address:
Article Synopsis
- The study examined how adding nitrogen fertilizers affects the remobilization of cadmium in rice fields, highlighting increased cadmium levels in rice due to ammonia nitrogen (NH-N) compared to nitrogen (NO-N).
- Organic acids secreted by rice roots, particularly under NH-N treatment, were found to play a significant role in increasing soluble cadmium content and impacting microbial community functions.
- The research suggests a complex interaction between nutrient application, cadmium levels, and microbial dynamics that could elevate cadmium exposure through rice consumption.
Rapid Determination of Organic and Inorganic Selenium in Poultry Tissues by Internal Extractive Electrospray Ionization Mass Spectrometry.
Anal Chem
January 2025
The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, P. R. China.
An online reactive internal extraction electrospray ionization (iEESI) method was developed for the rapid determination of organic and inorganic speciation information for selenium in poultry tissue samples without complex sample pretreatment. The addition of citric acid as a reducing agent to the internal extraction solvent of methanol/acetic acid (99:1, V/V) for iEESI resulted in the reduction of selenate in the sample to selenite, accompanied by the production of malic acid as an oxidation product. The quantitative analysis of selenate was conducted by using malic acid.
View Article and Find Full Text PDFDevelopment of a Wine Yeast Strain Capable of Malolactic Fermentation and Reducing the Ethyl Carbamate Content in Wine.
Foods
December 2024
Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.
In winemaking, malolactic fermentation (MLF), which converts L-malic acid to L-lactic acid, is often applied after the alcoholic fermentation stage to improve the sensory properties of the wine and its microbiological stability. MLF is usually performed by lactic acid bacteria, which, however, are sensitive to the conditions of alcoholic fermentation. Therefore, the development of wine yeast strains capable of both alcoholic fermentation and MLF is an important task.
View Article and Find Full Text PDFSynthesis and Characterization of Metal Particles Using Malic Acid-Derived Polyamides, Polyhydrazides, and Hydrazides.
Molecules
December 2024
School of Life Science, Shanxi University, Taiyuan 030006, China.
Malic acid-derived polyamides, polyhydrazides, and hydrazides exhibit strong potential for a variety of biological applications. This study demonstrates the synthesis of cobalt, silver, copper, zinc, and iron particles by a facile chemical reduction approach utilizing malic acid-derived polyamides, polyhydrazides, and hydrazides as stabilizing and reducing agents. Comprehensive characterization of the particles was performed using UV-Vis spectroscopy, FTIR, XRD, SEM, and EDX analysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!