AI Article Synopsis
- The enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) plays a crucial role in balancing fructose-2,6-bisphosphate levels, which is important for glucose regulation.
- Four genes (Pfkfb1-4) in mammals produce various isoforms of this enzyme through alternative splicing and different promoter usage.
- Researchers discovered new mRNA variants in fetal rat liver linked to a new promoter for the Pfkfb1 gene, leading to the creation of a long isoform (FL-PFK-2) that is vital for the metabolic transition from fetal to adult liver
Article Abstract
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.
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| http://dx.doi.org/10.1016/j.bbrc.2012.12.109 | DOI Listing |
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