Objective: To explore the expression of MICA/B in human esophageal cancer, and to analyze its correlation with clinicopathological features.
Methods: The expression of MICA/B in 40 cases of esophagus carcinoma and corresponding normal esophageal mucosa tissues were examined by immunohistochemistry.
Results: The positive rate of expression of MICA/B protein in the esophageal carcinoma was 75.0% (30/40), and that in the corresponding normal esophageal mucosa was 0 (0/40). Up-regulation of MICA/B expression was found in the esophageal carcinomas. The expression of MICA/B was related with histological grade of the esophageal carcinoma (P = 0.012).
Conclusion: MICA/B protein plays an important role in the esophageal carcinogenesis, and my become a useful molecular marker for the diagnosis of esophageal carcinoma.
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| http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2012.10.006 | DOI Listing |
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