[The factors predicting early efficacy of intravenous thrombolysis with alteplase in acute ischemic stroke].

Objective: To analyze the factors affecting on early efficacy of intravenous thrombolysis with alteplase.

Methods: The clinical data of 100 acute cerebral infarction patients treated by intravenous thrombolysis with alteplase were retrospectively analyzed. The patients were divided into early effective group and ineffective group, which assessed by National Institute of Health Stroke Scale (NIHSS) with criteria of whether there were > 3 or not at 24 hours after therapy. Univariate analysis and multivariate logistic regression analysis were used to determine the differences of clinical data between the two groups.

Results: Univariate analysis revealed that the early improvement was significantly associated with favorable outcome at 3 month (P = 0.000). Multivariate logistic analysis revealed that the systolic pressure at baseline was moderately positively associated with early improvement (OR 1.031, 95%CI 1.008 - 1.056, P = 0.009).

Conclusion: Moderately lower baseline systolic pressure is associated with early improvement after thrombolytic therapy which is associated with favorable outcome at 3 month.