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miR-1224 Controls Mammal Cerebral Cortex Development by Targeting the 3'-UTR of the Dlx1 mRNA.
J Cell Physiol
January 2025
Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Neural precursor cells (NPCs) are a group of cells with self-renewal and multi-differentiation potential. MicroRNAs are required for neurogenesis in the central nervous system (CNS). Recent reports suggest that miR-1224 is important in human CNS diseases.
View Article and Find Full Text PDFPortuguese Society of Ophthalmology and Portuguese Society of Human Genetics Joint Clinical Practice Guidelines for Genetic Testing in Inherited Retinal Dystrophies.
Clin Genet
January 2025
Centro de Responsabilidade Integrado de Oftalmologia Pediátrica (CRI-OftaPed), Hospital Dona Estefânia, Unidade Saúde Local (ULS) São José, E.P.E., Lisboa, Portugal.
The Portuguese Society of Ophthalmology and the Portuguese Society of Human Genetics developed clinical practice guidelines to streamline genetic testing for inherited retinal dystrophies (IRDs), underlining the critical role of molecular diagnosis in enhancing patient care. Genetic testing is pivotal in diagnosis, genetic counselling, prognosis and access to clinical trials, and new gene-specific therapies. These guidelines recommend genetic testing in all IRD patients and provide a detailed assessment of available testing methods, ensuring that genetic counselling is integrated into ophthalmic care.
View Article and Find Full Text PDFAssociation of nitric oxide levels and lipid profile with endothelial dysfunction in type 2 diabetic patients.
J Res Med Sci
October 2024
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.
Background: Evidence-based screening is crucial to detect myocardial ischemia in high-risk diabetics. We explored the relationship between nitric oxide (NO) levels, lipid profile indices, and atherogenic index of plasma (AIP) in type 2 diabetics with coronary artery disease (CAD) and to determine their potential as prognostic markers.
Materials And Methods: A case-control study included 50 diabetics with CAD (cases), 30 diabetics without CAD (control 1), and 23 healthy controls (control 2).
Clinical utility of synuclein skin biopsy in the diagnosis and evaluation of synucleinopathies.
Front Neurol
December 2024
Center of Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Introduction: The diagnosis of diseases known as synucleinopathies, Parkinson's disease (PD), multiple system atrophy (MSA) and Lewy body dementia (DLB), is predominantly based on clinical criteria. However, diagnostic uncertainty may persist until late in the disease process leading to delays in diagnosis and medical mismanagement. Skin biopsy detection of phosphorylated alpha-synuclein (P-SYN) is a sensitive and specific technique that increases diagnostic sensitivity of synucleinopathies, although the clinical utility of this test has not been fully explored.
View Article and Find Full Text PDFThe attention network characteristics of adults with high ADHD traits: low stability, boost accuracy by sacrificing response time.
Front Psychol
December 2024
Faculty of Psychology, Southwest University, Chongqing, China.
Adults with high ADHD traits (H-ADHD) face challenges in academics, social interactions, and careers, yet their attention characteristics remains unclear. Using Attention Network Test (ANT), we examine attentional characteristics (including specific attentional qualities and overall attentional performance) of H-ADHD and explore how their specific attentional qualities impact overall attentional performance. We find H-ADHD primarily manifests lower alerting network, higher intra-individual coefficient of variation (ICV) and poorer balanced integration score (BIS).
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