We synthesized a series of Seoul-Fluor-based lipid droplet bioprobes with a linear range of lipophilicity and identified SF44 and SF58 as SF-based LD bioprobes in microalgae for biofuel research as well as in mammalian cells. Unlike Nile Red, SF-based bioprobes can stain algal LDs with excellent efficiency under the non-invasive and non-cytotoxic conditions.
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Optimization of Seoul-Fluor-based lipid droplet bioprobes and their application in microalgae for bio-fuel study.
Mol Biosyst
May 2013
Department of Chemistry, Seoul National University, Seoul, Korea.
We synthesized a series of Seoul-Fluor-based lipid droplet bioprobes with a linear range of lipophilicity and identified SF44 and SF58 as SF-based LD bioprobes in microalgae for biofuel research as well as in mammalian cells. Unlike Nile Red, SF-based bioprobes can stain algal LDs with excellent efficiency under the non-invasive and non-cytotoxic conditions.
View Article and Find Full Text PDFA Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening.
Chem Commun (Camb)
February 2012
Department of Chemistry/Bio-MAX Institute, Seoul National University, Seoul 151-747, Korea.
We developed a novel fluorescent bioprobe (SF44) that can specifically visualize the cellular lipid droplets in in vitro and in vivo systems and illustrated the mechanistic rationale of its fluorogenic property. Its application to image-based high throughput screening led us to the identification of a new small-molecule modulator of lipid droplet formation.
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