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Accurate Analysis of Spectrophotometric Data to Quantify the Photoswitching Performance of a Biomimetic / Light-Induced Molecular Switch.
J Phys Chem B
January 2025
Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia, Via Elce di Sotto, 8, 06123 Perugia, Italy.
Photoswitches are widely investigated molecules because upon exposure to selected light irradiation, they are able to undergo structural, and hence optical, changes. To fully exploit their responsiveness to irradiation, the quantum efficiency of the forward and back reactions is a fundamental parameter, whose accurate determination is critical. In this work, the spectral evolution of a biomimetic switch, which undergoes / photoinduced isomerization, is spectrophotometrically examined.
View Article and Find Full Text PDFStability-indicating spectrophotometric quantification of safinamide in the presence of its possible degradation product.
Sci Rep
January 2025
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Badr City, 11829, Cairo, Egypt.
In recent times, a truly exquisite pharmaceutical marvel has graced the world of medicine, known as Safinamide (SAF). This opulent creation has been specifically tailored to cater to the needs of individuals afflicted with Parkinson's disease (PD), an esteemed neurological condition renowned for its regal ability to impede motor skills, coordination, and equilibrium. It is highly improbable that degradation products of pharmaceutical components would significantly compromise efficiency and safety of a drug during its shelf life.
View Article and Find Full Text PDFThe cumulative effect of ellagic acid and carnosic acid attenuates oxidative events during diabetic wound healing: in different applications and on different days.
Turk J Biol
October 2024
Department of Biology, Faculty of Science, Gazi University, Ankara, Turkiye.
Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds ellagic acid and carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats.
Materials And Methods: Diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment groups.
Cannabinoid receptor ligands modulate fibrosis and inflammation in idiopathic pulmonary fibrosis: a preliminary study.
Turk J Biol
October 2024
METU MEMS Center, Ankara, Turkiye.
Background/aim: No specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF) exists. Therefore, new antiinflammatory therapeutic strategies are needed. Cannabinoids (CBs), known for their inflammation-modulating and antifibrotic effects, may be potential medication candidates for treating IPF.
View Article and Find Full Text PDFA novel magnetic-assisted ionic liquid-based microextraction method (MA-ILBME): Specific design system for sensitive spectrophotometric analysis of paracetamol as a pharmaceutical pollutant in environmental samples.
Talanta
December 2024
Department of Chemistry, Faculty of Basic Sciences, Ayatollah Boroujerdi University, Boroujerd, Iran.
Monitoring paracetamol levels in environmental samples is essential, as this widely used pharmaceutical can degrade water quality and adversely affect both ecosystems and human health. To address this issue, a novel, simple, sensitive, and accurate method has been developed. This method employs a functionalized ionic liquid, 2-(4-hydroxybenzyl)hydrazinium chloride ([HBH][Cl]), specifically designed to structurally mimic paracetamol and function as a complexing agent.
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